All Phenotypes Hoxb6<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxb6^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2151485

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb6^tm1Mrc/Hoxb6^tm1Mrc	involves: 129S7/SvEvBrd	MGI:2673169
cx2	Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺	involves: 129S7/SvEvBrd	MGI:3611769
cx3	Hoxa6^tm1Mrc/Hoxa6^tm1Mrc Hoxb6^tm1Mrc/Hoxb6^tm1Mrc Hoxc6^tm1Dds/Hoxc6^tm1Dds	involves: 129S7/SvEvBrd	MGI:4358349
cx4	Hoxa5^tm1Rob/Hoxa5⁺ Hoxa6^tm1Mrc/Hoxa6⁺ Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺ Hoxc5^tm1Mrc/Hoxc5⁺ Hoxc6^tm1Dds/Hoxc6⁺	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:4358354

Allelic Composition	Hoxb6^tm1Mrc/Hoxb6^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb6^tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib morphology ( J:22424 )

• penetrance about 50%

absent proximal rib ( J:22424 )

• rarely, only the ventral portion of the first rib is present

• sometimes a gap exists between the dorsal and ventral portions of the first rib

decreased rib number ( J:22424 )

• absence or shortening of first rib

rib bifurcation ( J:22424 )

• bifurcation of the second rib so that the upper branch articulates with the top of the sternum

• bifurcation occurs at the point bone-cartilage junction in newborns

• first detectable around E11.5

abnormal vertebrae morphology ( J:22424 )

abnormal thoracic vertebrae morphology ( J:22424 )

• altered lateral processes on T1

thoracic vertebral transformation ( J:22424 )

• T1 to C7 transformation the most prevalent vertebral abnormality

cervical vertebral transformation ( J:22424 )

• C7 to C6 transformation

• tuberculum anterior of C6 either shifted to C7 (C6 to C5 transformation) or duplicated there

nervous system

abnormal somatic nervous system morphology ( J:22424 )

• path of first intercostals nerve altered due to the abnormal rib structures

Allelic Composition	Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb5^tm1Mrc mutation (0 available); any Hoxb5 mutation (12 available)
Hoxb6^tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

thoracic vertebral transformation ( J:22424 )

• T1 to C7 transformation frequent

cervical vertebral transformation ( J:22424 )

• C6 to C5 and/or C7 to C6 transformation in 52% of double heterozygotes

• occurs in the absence of T1 to C7 transformations

Allelic Composition	Hoxa6^tm1Mrc/Hoxa6^tm1Mrc Hoxb6^tm1Mrc/Hoxb6^tm1Mrc Hoxc6^tm1Dds/Hoxc6^tm1Dds
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa6^tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)
Hoxb6^tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)
Hoxc6^tm1Dds mutation (0 available); any Hoxc6 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternebra morphology ( J:124112 )

• sternebra are poorly formed or missing

small xiphoid process ( J:124112 )

• reduced or absent

short sternum ( J:124112 )

abnormal rib joint morphology ( J:124112 )

• rib projections extend from T2 through T6 with ribs from T2 through T4 exhibiting the same angle as T1 ribs

decreased rib number ( J:124112 )

• mice are missing a complete first rib

rib fusion ( J:124112 )

• from T2 to T4

small thoracic cage ( J:124112 )

vertebral transformation ( J:124112 )

• mice exhibit anterior homeotic transformation from C6 to T6

• however, posterior thoracic, lumbar, and sacral vertebrae are normal in appearance and position

thoracic vertebral transformation ( J:124112 )

• T2 does not form a rib

• anterior projections do not begin until T4 and continue through T6 unlike in wild-type mice

cervical vertebral transformation ( J:124112 )

• C7 exhibit a vertebral foramina unlike in wild-type mice

Allelic Composition	Hoxa5^tm1Rob/Hoxa5⁺ Hoxa6^tm1Mrc/Hoxa6⁺ Hoxb5^tm1Mrc/Hoxb5⁺ Hoxb6^tm1Mrc/Hoxb6⁺ Hoxc5^tm1Mrc/Hoxc5⁺ Hoxc6^tm1Dds/Hoxc6⁺
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5^tm1Rob mutation (1 available); any Hoxa5 mutation (27 available)
Hoxa6^tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)
Hoxb5^tm1Mrc mutation (0 available); any Hoxb5 mutation (12 available)
Hoxb6^tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)
Hoxc5^tm1Mrc mutation (0 available); any Hoxc5 mutation (12 available)
Hoxc6^tm1Dds mutation (0 available); any Hoxc6 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:124112 )

• primaxial and abaxial skeleton defects are less severe than in either triple homozygote

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