Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb5tm1Mrc mutation
(0 available);
any
Hoxb5 mutation
(12 available)
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skeleton
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• forelimbs shifted anteriorly relative to the axial skeleton
• shift of limbs sometimes is unilateral
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• rostral edge of the scapula aligns with C3 or C4 rather than C5
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• altered lateral processes on T1
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• T1 to C7 transformation the most prevalent vertebral abnormality
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• C7 to C6 transformation
• tuberculum anterior of C6 either shifted to C7 (C6 to C5 transformation) or duplicated there
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nervous system
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• brachial plexus enters the forelimb at a more posterior position than in controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb5tm1Mrc mutation
(0 available);
any
Hoxb5 mutation
(12 available)
Hoxb6tm1Mrc mutation
(0 available);
any
Hoxb6 mutation
(14 available)
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skeleton
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• T1 to C7 transformation frequent
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• C6 to C5 and/or C7 to C6 transformation in 52% of double heterozygotes
• occurs in the absence of T1 to C7 transformations
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5tm1Rob mutation
(1 available);
any
Hoxa5 mutation
(27 available)
Hoxb5tm1Mrc mutation
(0 available);
any
Hoxb5 mutation
(12 available)
Hoxc5tm1Mrc mutation
(0 available);
any
Hoxc5 mutation
(12 available)
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skeleton
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• the clavicles are attached to the rib cage by connective tissue and do not articulate directly with it unlike in wild-type mice
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• a eighth rib is attached to the sternum unlike in wild-type mice
• T1 ribs exhibit incomplete projection and T2 ribs extend but often do not reach the sternum (in 64% of mice)
• however, rib attachment posterior to T1 is normal
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• ribs initiate but do not extend on T1 unlike in wild-type mice
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• mice are missing a complete first rib
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• rib 2 and 3 are fused prior to attachment to the sternum
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• dorsal cartilage is thickened and forms a distinct curvature at the top of the vertebra unlike in wild-type mice
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• C3 through T2 exhibit anterior homeotic transformations
• C3 through T1 exhibit characteristics of C2
• however, posterior thoracic, lumbar, and sacral vertebrae are normal in appearance and position
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• C3 through T1 exhibit characteristics of C2
• T2 lacks anterior projections and is similar to T3
• ibs do not extend on T1 unlike in wild-type mice
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• C3 through T1 exhibit characteristics of C2
• vertebral foramina extend beyond C6 to C7 unlike in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5tm1Rob mutation
(1 available);
any
Hoxa5 mutation
(27 available)
Hoxa6tm1Mrc mutation
(0 available);
any
Hoxa6 mutation
(9 available)
Hoxb5tm1Mrc mutation
(0 available);
any
Hoxb5 mutation
(12 available)
Hoxb6tm1Mrc mutation
(0 available);
any
Hoxb6 mutation
(14 available)
Hoxc5tm1Mrc mutation
(0 available);
any
Hoxc5 mutation
(12 available)
Hoxc6tm1Dds mutation
(0 available);
any
Hoxc6 mutation
(11 available)
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skeleton
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• primaxial and abaxial skeleton defects are less severe than in either triple homozygote
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