Phenotypes associated with this allele
Allelic
Composition |
Hoxa9tm1Ipc/Hoxa9tm1Ipc
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Genetic
Background |
either: 129/Sv-Hoxa9tm1Ipc or (involves: 129/Sv * 129S2/SvPas * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9tm1Ipc mutation
(0 available);
any
Hoxa9 mutation
(17 available)
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skeleton
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• lumbar vertebrae are anteriorized with extra ribs on vertebrae 21 indicating an L1 to T transformation
• vertebrae 21 through 25 are anteriorized
• however, L6 is normal
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Allelic
Composition |
Hoxa9tm1Ipc/Hoxa9+
|
|
Genetic
Background |
either: 129/Sv-Hoxa9tm1Ipc or (involves: 129/Sv * 129S2/SvPas * C57BL/6) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9tm1Ipc mutation
(0 available);
any
Hoxa9 mutation
(17 available)
|
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skeleton
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• 60% of mice exhibit partial, and sometimes asymmetric, rib rudiments on L1
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• 60% of mice exhibit partial anteriorization with partial, and sometimes asymmetric, rib rudiments on L1
• 60% of mice exhibit unilateral or bilateral transformations of vertebrae 22 to 25
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9tm1Ipc mutation
(0 available);
any
Hoxa9 mutation
(17 available)
Hoxd9tm1Ipc mutation
(0 available);
any
Hoxd9 mutation
(16 available)
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reproductive system
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• 5 out of 11 females are sterile
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• females produce small litters that often die one day after birth
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• 5 out of 10 males are sterile
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skeleton
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• abnormal humerus morphology are visible as early as P2
• the proximal head is flattened in some mice
• in some mice the articular surface of the head is abnormal
• some mice exhibit ectopic sesamoid bones in the elbow region with 5 of 14 mice exhibiting a small supernumery bone on the lateral side, 5 of 14 mice exhibiting a supernumerary sesamoid on the medial side, and 2 of 14 mice exhibiting a large supernumerary sesamoid along the crania side of the elbow joint
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• in some mice the deltoid is absent except for a distal rudiment consisting of either a small floating bone or bony protrusion
in some mice the deltoid is severely truncated
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• mice exhibit an extra pair of ribs on vertebra 24
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• the articulation joining the ilium to the vertebral column is shifted half a vertebra
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• caudal vertebrae through Ca2 are anteriorized
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• mice exhibit anteriorization of L1 to T13 with an extra pair of ribs
• all lumbar vertebrae are anteriorized
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• sacral vertebrae are anteriorized
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limbs/digits/tail
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• abnormal humerus morphology are visible as early as P2
• the proximal head is flattened in some mice
• in some mice the articular surface of the head is abnormal
• some mice exhibit ectopic sesamoid bones in the elbow region with 5 of 14 mice exhibiting a small supernumery bone on the lateral side, 5 of 14 mice exhibiting a supernumerary sesamoid on the medial side, and 2 of 14 mice exhibiting a large supernumerary sesamoid along the crania side of the elbow joint
|
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• in some mice the deltoid is absent except for a distal rudiment consisting of either a small floating bone or bony protrusion
in some mice the deltoid is severely truncated
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• caudal vertebrae through Ca2 are anteriorized
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Allelic
Composition |
Hoxa9tm1Ipc/Hoxa9+
Hoxd9tm1Ipc/Hoxd9+
|
|
Genetic
Background |
involves: 129/Sv * 129S2/SvPas * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9tm1Ipc mutation
(0 available);
any
Hoxa9 mutation
(17 available)
Hoxd9tm1Ipc mutation
(0 available);
any
Hoxd9 mutation
(16 available)
|
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skeleton
|
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• some mice exhibit partial anteriorization of vertebrae 21 to 25
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9tm1Ipc mutation
(0 available);
any
Hoxa9 mutation
(17 available)
Hoxd9tm1Ipc mutation
(0 available);
any
Hoxd9 mutation
(16 available)
|
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skeleton
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• more affected than in Hoxd9tm1Ipc homozygotes
|
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• 12% to 15% of mice exhibit a reduction in humerus length that is between that observed in Hoxd9tm1Ipc homozygotes and Hoxa9tm1Ipc Hoxd9tm1Ipc homozygotes
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• 30% of mice exhibit the sum of vertebral column defects observed in Hoxd9tm1Ipc homozygotes and Hoxa9tm1Ipc heterozygotes
• 50% of mice exhibit vertebral column phenotypes observed in Hoxa9tm1Ipc Hoxd9tm1Ipc homozygotes
• 20% of mice exhibit unilateral transformation of vertebra 26 to L5, 27 to L6, and 28 to S1
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• 20% of mice exhibit anteriorization of vertebra 27 to L6
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• 20% of mice exhibit anteriorization of vertebra 28 and 29 to L6 and S1, respectively
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limbs/digits/tail
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• more affected than in Hoxd9tm1Ipc homozygotes
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• 12% to 15% of mice exhibit a reduction in humerus length that is between that observed in Hoxd9tm1Ipc homozygotes and Hoxa9tm1Ipc Hoxd9tm1Ipc homozygotes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa9tm1Ipc mutation
(0 available);
any
Hoxa9 mutation
(17 available)
Hoxd9tm1Ipc mutation
(0 available);
any
Hoxd9 mutation
(16 available)
|
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skeleton
|
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• 60% of mice exhibit vertebral column phenotypes observed in Hoxa9tm1Ipc homozygotes
40% of mice exhibit vertebral column phenotypes observed in Hoxa9tm1Ipc Hoxd9tm1Ipc homozygotes
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limbs/digits/tail
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N |
• mice exhibit normal humerus morphology
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Analysis Tools