About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epha4tm1Pch
targeted mutation 1, Patrick Charnay
MGI:2149729
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epha4tm1Pch/Epha4tm1Pch involves: 129S2/SvPas * CD-1 MGI:3851500
cx2
 		Chn1Gt714Lex/Chn1+
Epha4tm1Pch/Epha4+ 		involves: 129S2/SvPas * 129S5/SvEvBrd MGI:3809834


Genotype
MGI:3851500
hm1
Allelic
Composition		 Epha4tm1Pch/Epha4tm1Pch
Genetic
Background		 involves: 129S2/SvPas * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1Pch mutation (1 available); any Epha4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are thinner and less robust than in wild-type mice




Genotype
MGI:3809834
cx2
Allelic
Composition		 Chn1Gt714Lex/Chn1+
Epha4tm1Pch/Epha4+
Genetic
Background		 involves: 129S2/SvPas * 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn1Gt714Lex mutation (0 available); any Chn1 mutation (44 available)
Epha4tm1Pch mutation (1 available); any Epha4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:128698 )
• synchronous hind limb movement, rabbit like hopping gait

nervous system
abnormal spinal cord interneuron morphology ( J:128698 )
• increased number of lumbar region interneurons cross the midline
abnormal spinal cord dorsal column morphology ( J:128698 )
• shallow, broader, dorsal funiculus




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory