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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Epha4tm1Pch
targeted mutation 1, Patrick Charnay
MGI:2149729
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Epha4tm1Pch/Epha4tm1Pch involves: 129S2/SvPas * CD-1 MGI:3851500
cx2
 		Chn1Gt714Lex/Chn1+
Epha4tm1Pch/Epha4+ 		involves: 129S2/SvPas * 129S5/SvEvBrd MGI:3809834


Genotype
MGI:3851500
hm1
Allelic
Composition		 Epha4tm1Pch/Epha4tm1Pch
Genetic
Background		 involves: 129S2/SvPas * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha4tm1Pch mutation (1 available); any Epha4 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are thinner and less robust than in wild-type mice




Genotype
MGI:3809834
cx2
Allelic
Composition		 Chn1Gt714Lex/Chn1+
Epha4tm1Pch/Epha4+
Genetic
Background		 involves: 129S2/SvPas * 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn1Gt714Lex mutation (0 available); any Chn1 mutation (44 available)
Epha4tm1Pch mutation (1 available); any Epha4 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:128698 )
• synchronous hind limb movement, rabbit like hopping gait

nervous system
abnormal spinal cord interneuron morphology ( J:128698 )
• increased number of lumbar region interneurons cross the midline
abnormal spinal cord dorsal column morphology ( J:128698 )
• shallow, broader, dorsal funiculus




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory