Phenotypes associated with this allele

• Allele Symbol: Maf^tm1Mym
• Allele Name: targeted mutation 1, Masayuki Yamamoto
• Allele ID: MGI:2148637
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Maf^tm1Mym/Maf^tm1Mym	either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * ICR)	MGI:3774593

Genotype
MGI:3774593

hm1

• Allelic Composition: Maf^tm1Mym/Maf^tm1Mym
• Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Maf^tm1Mym/Maf^tm1Mym mice lack normal lens structure

mortality/aging

postnatal lethality, complete penetrance ( J:56095 )

• all mice are dead prior to 1 month of age

embryonic lethality during organogenesis, incomplete penetrance ( J:56095 )

• fewer than expected embryos are present at E12.5

vision/eye

abnormal lens development ( J:56095 )

• despite normal lens vesicle at E11.5, at E16.5 mice lack normal lens structures and elongating lens fiber cells

• at E16.5, the lens cavity is empty instead of full as in wild-type mice

abnormal lens fiber morphology ( J:56095 )

• at E16.5 mice lack normal elongating lens fiber cells