Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apcstm1Mpe mutation
(0 available);
any
Apcs mutation
(21 available)
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mortality/aging
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• mice exhibit decreased mortality when infected with S. pyogenes
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• mice exhibit increased mortality when infected with E. coli compared to wild-type mice
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immune system
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N |
• Background Sensitivity: unlike mice on a C56BL/6 background, mice on a 129 background do not develop increased autoimmune antibodies spontaneously or following induction by active immunization
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• infrequent and moderate
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• mice exhibit decreased mortality when infected with S. pyogenes
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• mice exhibit increased mortality when infected with E. coli compared to wild-type mice
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renal/urinary system
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• infrequent and moderate
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apcstm1Mpe mutation
(0 available);
any
Apcs mutation
(21 available)
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mortality/aging
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• mice exhibit increased survival when infected with rough E. coli J5 strain
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• mice exhibit increased susceptibility to infected with E. coli compared to wild-type mice
• treatment of mice with 10 mg/kg LPS exhibit accelerated mortality compared to wild-type mice
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immune system
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• mice exhibit red pulp lymphocytosis
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• mice exhibit coalescence of white pulp
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• with females more affected
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• mice, particularly females, exhibit a higher frequency and severity of proliferative, immune complex glomerulonephritis compared to wild-type and heterozygous mice
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• mice exhibit greater killing of E. coli J5 strain than wild-type mice
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• mice exhibit increased survival when infected with rough E. coli J5 strain
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• mice exhibit increased susceptibility to infected with E. coli compared to wild-type mice
• treatment of mice with 10 mg/kg LPS exhibit accelerated mortality compared to wild-type mice
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renal/urinary system
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• mice, particularly females, exhibit a higher frequency and severity of proliferative, immune complex glomerulonephritis compared to wild-type and heterozygous mice
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hematopoietic system
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• mice exhibit red pulp lymphocytosis
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• mice exhibit coalescence of white pulp
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apcstm1Mpe mutation
(0 available);
any
Apcs mutation
(21 available)
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normal phenotype
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• normal development and fertility; no obvious defect detected up to 11 months of age
• resistance to induction of reactive amyloidosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apcstm1Mpe mutation
(0 available);
any
Apcs mutation
(21 available)
|
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immune system
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• mice exhibit red pulp lymphocytosis
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• mice exhibit coalescence of white pulp
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• intermediate increase with females more affected
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• mice, particularly females, exhibit intermediate frequency of proliferative, immune complex glomerulonephritis compared to wild-type mice
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renal/urinary system
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• mice, particularly females, exhibit intermediate frequency of proliferative, immune complex glomerulonephritis compared to wild-type mice
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hematopoietic system
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• mice exhibit red pulp lymphocytosis
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• mice exhibit coalescence of white pulp
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Analysis Tools