Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pitx2tm2Jfm targeted mutation 2, James F Martin MGI:2136269 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• orientation of the molars is abnormal
|
|
• orientation of the molars is abnormal
|
|
• orientation of the molars is abnormal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• molars arrest prior to cap formation
|
|
• molars arrest prior to cap formation
|
|
• molars arrest prior to cap formation
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Axenfeld-Rieger syndrome type 1 | DOID:0110120 |
OMIM:180500 |
J:87220 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• about 50% of mutant embryos die by E16.5
|
|
• trabeculation of the right and left atria are similar, unlike in wild-type embryos where more extensive trabeculation is seen in the right atrium
|
|
• the left-sided branching pattern is right isomerized
|
|
• in about 14% of mutants rotation of the duodenum does not occur and in about 36% rotation is reversed
|
|
• the left-sided branching pattern is right isomerized
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
