Phenotypes associated with this allele

• Allele Symbol: Myf5^{tm2(Pdgfa)Sor}
• Allele Name: targeted mutation 2, Philippe Soriano
• Allele ID: MGI:2135564
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf5^tm2(Pdgfa)Sor/Myf5^tm2(Pdgfa)Sor	involves: 129S4/SvJae * C57BL/6J	MGI:3713923

Genotype
MGI:3713923

hm1

• Allelic Composition: Myf5^{tm2(Pdgfa)Sor}/Myf5^{tm2(Pdgfa)Sor}
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:65301 )

• animals die at birth

skeleton

abnormal thoracic cage morphology ( J:65301 )

• increased rib development leads to substantial rib cage formation relative to Myf5 null mice

abnormal rib morphology ( J:65301 )

• increased bone formation in distal and proximal ribs is observed in E18.5 animals

• some ribs are thicker than wild-type, Myf5^tm1Jae, or Myf5^tm3(cre)Sor homozygous embryos

abnormal rib development ( J:65301 )

• amount of rib formation is bilaterally asymmetric; ribs 1,4, and 11-13 show frequent abnormalities

increased rib number ( J:65301 )

• supernumerary rib structures that are either floating or linked to other ribs in anterior to posterior direction are observed

abnormal cervical vertebrae morphology ( J:65301 )

• increased bone formation is observed in embryos at E18.5

cervical vertebral fusion ( J:65301 )

• only observed in one animal

increased bone ossification ( J:65301 )

• animals show increased bone formation compared to other knockin animals

muscle

abnormal myotome development ( J:65301 )

• at E9 and E10 myotome formation is abnormal with no expression of myogenin transcripts or myosin heavy chain protein detected