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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcer2atm1Putt
targeted mutation 1, Herman van der Putten
MGI:1934933
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fcer2atm1Putt/Fcer2atm1Putt involves: 129S/SvEv * C57BL/6 MGI:3845974
ht2
 		Fcer2atm1Putt/Fcer2a+ involves: 129S/SvEv * C57BL/6 MGI:3845975


Genotype
MGI:3845974
hm1
Allelic
Composition		 Fcer2atm1Putt/Fcer2atm1Putt
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer2atm1Putt mutation (0 available); any Fcer2a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell proliferation ( J:69547 )
• B cell proliferation in response to BCR stimulation is reduced by about 25%
• no significant differences in activation occur when CD40 co-stimulation is performed

hematopoietic system
abnormal B cell proliferation ( J:69547 )
• B cell proliferation in response to BCR stimulation is reduced by about 25%
• no significant differences in activation occur when CD40 co-stimulation is performed

cellular
abnormal B cell proliferation ( J:69547 )
• B cell proliferation in response to BCR stimulation is reduced by about 25%
• no significant differences in activation occur when CD40 co-stimulation is performed




Genotype
MGI:3845975
ht2
Allelic
Composition		 Fcer2atm1Putt/Fcer2a+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer2atm1Putt mutation (0 available); any Fcer2a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgE level ( J:69547 )
• IgE levels are 2-3 fold higher upon primary and secondary infection with Nippostrongylus brasiliensis

hematopoietic system
increased IgE level ( J:69547 )
• IgE levels are 2-3 fold higher upon primary and secondary infection with Nippostrongylus brasiliensis




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory