All Phenotypes Phox2b<Dilp1> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Phox2b^Dilp1
dilated pupils 1
MGI:1934628

Summary

2 genotypes

Allelic Composition	Phox2b^Dilp1/Phox2b^Dilp1
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^Dilp1 mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:75964 )

Allelic Composition	Phox2b^Dilp1/Phox2b⁺
Genetic Background	involves: BALB/cAnN * C3H/HeN

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2b^Dilp1 mutation (0 available); any Phox2b mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• abnormal Mendelian ratios suggested that some heterozygous mice die before weaning

vision/eye

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

abnormal eye morphology ( J:75964 )

mydriasis ( J:75964 , J:91199 )

behavior/neurological

impaired pupillary reflex ( J:91199 )

• exhibit no pupillary response to light

• pupils fail to constrict in response to the parasympathetic agonist, carbachol

nervous system

• exhibit severe atrophy of the ciliary ganglia at E13.5

• however, the superior cervical ganglion is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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