Phenotypes associated with this allele

• Allele Symbol: Inpp4a^wbl
• Allele Name: weeble
• Allele ID: MGI:1934584
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inpp4a^wbl/Inpp4a^wbl	C57BL/6J-A^w	MGI:2668586
ht2	Inpp4a^tm1Tsak/Inpp4a^wbl	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:4462382

Genotype
MGI:2668586

hm1

• Allelic Composition: Inpp4a^wbl/Inpp4a^wbl
• Genetic Background: C57BL/6J-A^w

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:72427 )

• mice usually die by P24; posture suggests that mice die from maximal seizures, although a general failure to thrive cannot be excluded

behavior/neurological

impaired righting response ( J:72427 )

ataxia ( J:72427 )

• severe, related to cerebellar defects; detectable at P14

growth/size/body

decreased body size ( J:72427 )

nervous system

thin external granule cell layer ( J:72427 )

hippocampal neuron degeneration ( J:72427 )

• pronounced pyramidal cell loss detected at P21

Purkinje cell degeneration ( J:72427 )

• detected as early as P6, widespread by P8, and severe by P12

small cerebellum ( J:72427 )

• detected as early as P8 with further degeneration noted at P21

Genotype
MGI:4462382

ht2

• Allelic Composition: Inpp4a^tm1Tsak/Inpp4a^wbl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

behavior/neurological

abnormal involuntary movement ( J:161963 )

nervous system

neurodegeneration ( J:161963 )