All Phenotypes Hoxb8<tm1.1Jdes> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxb8^tm1.1Jdes
targeted mutation 1.1, Jacqueline Deschamps
MGI:1934178

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes	involves: 129P2/OlaHsd * FVB	MGI:2675268
ht2	Hoxb8^tm1.1Jdes/Hoxb8⁺	involves: 129P2/OlaHsd * FVB	MGI:3840808
cx3	Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes Hoxc8^tm1Phb/?	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N	MGI:3610487
cx4	Hoxb8^tm1.1Jdes/? Hoxc8^tm1Phb/Hoxc8^tm1Phb Hoxd8^tm1Jdes/Hoxd8^tm1Jdes	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N	MGI:3610494
cx5	Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes Hoxd8^tm1Jdes/?	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N	MGI:3610490

Allelic Composition	Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8^tm1.1Jdes mutation (0 available); any Hoxb8 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternum morphology ( J:68720 )

• often a reduced number of segments

abnormal sternocostal joint morphology ( J:58621 )

• in 33% of mice, T1 and T2 ribs fused before attachment to sternum or attach at the same point in some mice

asymmetric rib joints ( J:68720 )

• unilateral shift in rib attachments in some mice

abnormal rib morphology ( J:68720 )

• various rib abnormalities

cervical vertebral transformation ( J:68720 )

• C7 to C6 transformation in some instances

nervous system

abnormal dorsal root ganglion morphology ( J:58621 )

• 2nd spinal ganglion (C2) abnormal - degeneration by E12.5 affecting shape and position

• all mice exhibit abnormal rostral and caudal left side C2 spinal ganglion

• 4 of 5 and 3 of 5 mice exhibit abnormal rostral and caudal moieties, respectively, of the right side of the C2 spinal ganglion

growth/size/body

postnatal growth retardation ( J:58621 )

• normal size at birth but growth lagged subsequently

• however, growth recovers after weaning

behavior/neurological

limb grasping ( J:58621 )

• both fore and hind limbs

• stretch limbs and then pull them back toward middle of body

abnormal gait ( J:58621 )

• hind limbs are raised higher than normal while walking

integument

skin lesions ( J:58621 )

• develop on the back in about 1/3 of mice during life

• can be large wounds

• sometimes extend into deeper tissues

Allelic Composition	Hoxb8^tm1.1Jdes/Hoxb8⁺
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8^tm1.1Jdes mutation (0 available); any Hoxb8 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal root ganglion morphology ( J:58621 )

• 4 of 4 mice exhibit abnormal rostral moiety of the left side of the C2 spinal ganglion

• 3 of 4 mice exhibit abnormal rostral moiety of the right side of the C2 spinal ganglion

• mice exhibit degeneration of the C2 spinal ganglion unlike in wild-type mice

• the C2 ganglia is abnormal in shape and position

abnormal spinal nerve morphology ( J:58621 )

• one mouse lacked the venral ramus of the second spinal nerve while it is thinner in other mice compared to in wild-type mice

skeleton

abnormal sternocostal joint morphology ( J:58621 )

• in 6% of mice, rib to sternum attachment points exhibit defects ranging from unilateral inversion of the point of attachment of T1 and T2 to unilateral shifts of the points of attachments of T1 to T5 unlike in wild-type mice

Allelic Composition	Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes Hoxc8^tm1Phb/?
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8^tm1.1Jdes mutation (0 available); any Hoxb8 mutation (8 available)
Hoxc8^tm1Phb mutation (0 available); any Hoxc8 mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:68720 )

• enhanced upper thoracic abnormalities

abnormal rib joint morphology ( J:68720 )

• less frequent 8th rib attachment to sternum

sacral vertebral transformation ( J:68720 )

• increased prevalence of S1 to L6 transformation

Allelic Composition	Hoxb8^tm1.1Jdes/? Hoxc8^tm1Phb/Hoxc8^tm1Phb Hoxd8^tm1Jdes/Hoxd8^tm1Jdes
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal thoracic cage morphology ( J:68720 )

• upper ribcage abnormalities are much more prevalent

asymmetric sternocostal joints ( J:68720 )

• bilateral attachment of extra ribs to sternum is less common

increased rib number ( J:68720 )

• presence of L1 ribs less prevalent

thoracic vertebral transformation ( J:68720 )

• T8 to T7 transformation less frequent and not as severe as when Hoxc8^tm1Phb only was mutated

Allelic Composition	Hoxb8^tm1.1Jdes/Hoxb8^tm1.1Jdes Hoxd8^tm1Jdes/?
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8^tm1.1Jdes mutation (0 available); any Hoxb8 mutation (8 available)
Hoxd8^tm1Jdes mutation (0 available); any Hoxd8 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:68720 )

• enhanced upper thoracic abnormalities

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