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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il1raptm1Roml
targeted mutation 1, Mark A Labow
MGI:1934017
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il1raptm1Roml/Il1raptm1Roml involves: 129S1/Sv MGI:3586692
cx2
 		Il1raptm1Roml/Il1rap+
Tg(KRT14-Il1f6)1Hblu/? 		involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:3762038
cx3
 		Il1raptm1Roml/Il1raptm1Roml
Tg(KRT14-Il1f6)1Hblu/? 		involves: 129S1/Sv * C57BL/6 * DBA/2 MGI:3762039


Genotype
MGI:3586692
hm1
Allelic
Composition		 Il1raptm1Roml/Il1raptm1Roml
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1raptm1Roml mutation (1 available); any Il1rap mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-6 secretion ( J:68065 )
• failure of tissues to secrete Il-6 in response to Il1 injections as occurs in control mice
• mice otherwise normal

integument
integument phenotype ( J:126327 )
N
• mice have normal skin




Genotype
MGI:3762038
cx2
Allelic
Composition		 Il1raptm1Roml/Il1rap+
Tg(KRT14-Il1f6)1Hblu/?
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1raptm1Roml mutation (1 available); any Il1rap mutation (54 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal skin morphology ( J:126327 )
• mice exhibit an abnormal skin phenotype similar to that observed in Tg(KRT14-Il1f5)1Hblu mice




Genotype
MGI:3762039
cx3
Allelic
Composition		 Il1raptm1Roml/Il1raptm1Roml
Tg(KRT14-Il1f6)1Hblu/?
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1raptm1Roml mutation (1 available); any Il1rap mutation (54 available)
Tg(KRT14-Il1f6)1Hblu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:126327 )
N
• mice have normal skin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory