Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk3tm1Par mutation
(0 available);
any
Ntrk3 mutation
(65 available)
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mortality/aging
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• die within several days after birth
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nervous system
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• majority of sensory neuron loss occurs before E13.5
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk3tm1Par mutation
(0 available);
any
Ntrk3 mutation
(65 available)
|
|
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Malformations in cardiogenesis of Ntrk3tm1Par/Ntrk3tm1Par mice
growth/size/body
mortality/aging
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• 90% die by P6 and none live longer than P25
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cardiovascular system
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• hypertrophy and thickening of the pulmonary veins as they branch within the lung parenchyma
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• exhibit abnormalities in septation of the cardiac outflow tract and one homozygote developed truncus arteriosis
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• majority exhibit defects in chamber septation
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• 4/8 exhibit large atrial secundum defects
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• 3/8 exhibit large ventricular septal defects
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• exhibit valvular defects
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• hypertrophy/hyperplasia of the pulmonic valve
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• hypertrophy/hyperplasia of the pulmonic valve
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• seen in 3/8 homozygotes
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• significant right ventricular chamber enlargement
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nervous system
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• loss of Ia proprioceptive neuronal fibers that terminate in lamina IX of the spinal cortex
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• loss of Ia proprioceptive neuronal fibers that terminate in lamina IX of the spinal cortex
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• 70% reduction of neurons in the cochlear ganglion
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• 14% reduction of neurons in the petrosal-nodose ganglion
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• 21% reduction of neurons in the trigeminal ganglion
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• 14% reduction of neurons in the petrosal-nodose ganglion
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• 15% reduction of neurons in the vestibular ganglion
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• 33% reduction of neurons in the dorsal root ganglia at L5 level
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respiratory system