Phenotypes associated with this allele

• Allele Symbol: Ntrk3^tm1Par
• Allele Name: targeted mutation 1, Luis F Parada
• Allele ID: MGI:1933975
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk3^tm1Par/Ntrk3^tm1Par	involves: 129S1/Sv	MGI:3612891
hm2	Ntrk3^tm1Par/Ntrk3^tm1Par	involves: 129S1/Sv * C57BL/6	MGI:2175191

Genotype
MGI:3612891

hm1

• Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:44286 )

• die within several days after birth

nervous system

decreased sensory neuron number ( J:44286 )

• majority of sensory neuron loss occurs before E13.5

Genotype
MGI:2175191

hm2

• Allelic Composition: Ntrk3^tm1Par/Ntrk3^tm1Par
• Genetic Background: involves: 129S1/Sv * C57BL/6

Malformations in cardiogenesis of Ntrk3^tm1Par/Ntrk3^tm1Par mice

growth/size/body

enlarged heart ( J:45083 )

mortality/aging

postnatal lethality, complete penetrance ( J:45083 )

• 90% die by P6 and none live longer than P25

cardiovascular system

abnormal pulmonary vein morphology ( J:45083 )

• hypertrophy and thickening of the pulmonary veins as they branch within the lung parenchyma

abnormal cardiac outflow tract development ( J:45083 )

abnormal truncus arteriosus septation ( J:45083 )

• exhibit abnormalities in septation of the cardiac outflow tract and one homozygote developed truncus arteriosis

abnormal heart septum morphology ( J:45083 )

• majority exhibit defects in chamber septation

ostium secundum atrial septal defect ( J:45083 )

• 4/8 exhibit large atrial secundum defects

ventricular septal defect ( J:45083 )

• 3/8 exhibit large ventricular septal defects

globular heart ( J:45083 )

enlarged heart ( J:45083 )

abnormal heart valve morphology ( J:45083 )

• exhibit valvular defects

abnormal mitral valve morphology ( J:45083 )

abnormal tricuspid valve morphology ( J:45083 )

abnormal aortic valve morphology ( J:45083 )

pulmonary valve hyperplasia ( J:45083 )

• hypertrophy/hyperplasia of the pulmonic valve

pulmonary valve hypertrophy ( J:45083 )

• hypertrophy/hyperplasia of the pulmonic valve

pulmonary valve stenosis ( J:45083 )

• seen in 3/8 homozygotes

dilated heart right ventricle ( J:45083 )

• significant right ventricular chamber enlargement

lung hemorrhage ( J:45083 )

• hemorrhages

nervous system

decreased sensory neuron number ( J:45083 )

• loss of Ia proprioceptive neuronal fibers that terminate in lamina IX of the spinal cortex

abnormal proprioceptive neuron morphology ( J:45083 )

• loss of Ia proprioceptive neuronal fibers that terminate in lamina IX of the spinal cortex

abnormal cranial ganglia morphology ( J:45083 )

small cochlear ganglion ( J:45083 )

• 70% reduction of neurons in the cochlear ganglion

small petrosal ganglion ( J:45083 )

• 14% reduction of neurons in the petrosal-nodose ganglion

small trigeminal ganglion ( J:45083 )

• 21% reduction of neurons in the trigeminal ganglion

small nodose ganglion ( J:45083 )

• 14% reduction of neurons in the petrosal-nodose ganglion

small vestibular ganglion ( J:45083 )

• 15% reduction of neurons in the vestibular ganglion

small L5 dorsal root ganglion ( J:45083 )

• 33% reduction of neurons in the dorsal root ganglia at L5 level

respiratory system

lung hemorrhage ( J:45083 )

• hemorrhages