Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr2tm1Hmo mutation
(1 available);
any
Cr2 mutation
(84 available)
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homeostasis/metabolism
renal/urinary system
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N |
• no significant effect on renal ischemia reperfusion injury
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immune system
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• mice are more susceptible to pneumococcal infection than controls
• when challenged with a PspA- bacterial strain, mice have a 10-fold higher burden 4 hours after infection
• mice on average die 3.5 days after infection compared to none in wild-type controls
• only 20% of mice survive infection while all wild-type controls survive
• only 12% of mice survive infection with a more virulent PspA+ strain compared to 42% of controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr2tm1Hmo mutation
(1 available);
any
Cr2 mutation
(84 available)
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immune system
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• although serum levels of IgG in general are normal in unimmunized mice, a significantly reducted response of IgG1 occurs after immunization with T-cell dependent antigen
• a significantly reducted response of IgG2a, IgG2b and IgG3 occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls
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• although serum levels are normal in unimmunized mice, a significant reduction in response occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls
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hematopoietic system
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• although serum levels of IgG in general are normal in unimmunized mice, a significantly reducted response of IgG1 occurs after immunization with T-cell dependent antigen
• a significantly reducted response of IgG2a, IgG2b and IgG3 occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls
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• although serum levels are normal in unimmunized mice, a significant reduction in response occurs after immunization with T-cell dependent antigen
• secondary response is increased several fold over primary response but is still significantly below that of controls
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Allelic
Composition |
Cr2tm1Hmo/Cr2tm1Hmo
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Genetic
Background |
involves: 129S7/SvEvBrd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr2tm1Hmo mutation
(1 available);
any
Cr2 mutation
(84 available)
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immune system
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• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen
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• B cells fail to internalize complement coated immune complexes
• bone marrow chimeric mice containing mutant B cells fail to produce antigen-specific antibodies
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• bone marrow chimeric mice have reduced ability in class switch recombination in response to low dose antigen
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• B cells fail to react to sub-optimal doses of antigen coated in C3 complement
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hematopoietic system
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• bone marrow chimeric mice have reduced ability to generate memory B cells in response to low-dose antigen
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• B cells fail to internalize complement coated immune complexes
• bone marrow chimeric mice containing mutant B cells fail to produce antigen-specific antibodies
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• bone marrow chimeric mice have reduced ability in class switch recombination in response to low dose antigen
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• B cells fail to react to sub-optimal doses of antigen coated in C3 complement
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Analysis Tools