Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Sjk mutation
(0 available);
any
Kmt2a mutation
(135 available)
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mortality/aging
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• mice die by E10.5
(J:29958)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Sjk mutation
(0 available);
any
Kmt2a mutation
(135 available)
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nervous system
muscle
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• fewer migratory myoblasts that are less organized than in wild-type mice
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cellular
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• fewer migratory myoblasts that are less organized than in wild-type mice
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Allelic Composition |
Kmt2atm1Sjk/Kmt2a+
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Genetic Background |
involves: 129S2/SvPas * C3H * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Sjk mutation
(0 available);
any
Kmt2a mutation
(135 available)
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reproductive system
skeleton
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• 20 of 22 mice exhibit manubriosternebral abnormalities
• 17 of 22 mice exhibit xiphosternebral malformations
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• mice exhibit a complete loss or partial rib lose at T13
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• mice exhibit C7/T13/L5 or C7/T12/L6 instead of C7/T13/L6 as in wild-type mice
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• 18 of 22 mice exhibit T3 to T2 transformations
• 16 of 22 mice exhibit T2 to T1 transformations
• 8 of 22 mice exhibit T13 to L1 transformations
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• 14 of 22 mice exhibit C2 malformations compared to 4 of 29 mice
• 17 of 22 mice exhibit C7 to C6 transformations
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• 19 of 22 mice exhibit L6 to S1 transformations
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hematopoietic system
growth/size/body
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• mice are small at birth
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immune system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.2Erns mutation
(0 available);
any
Kmt2a mutation
(135 available)
Kmt2atm1Sjk mutation
(0 available);
any
Kmt2a mutation
(135 available)
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