Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Proztm1Gjb mutation
(0 available);
any
Proz mutation
(29 available)
|
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mortality/aging
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• mice show increased mortality in a collagen/epinephrine-induced thromboembolism model, with 71% of mice dying of respiratory arrest within 5 minutes of model induction compared to 27% in wild-type mice
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Proztm1Gjb mutation
(0 available);
any
Proz mutation
(29 available)
|
|
|
normal phenotype
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• mice show normal growth and development, and hematopoietic parameters are grossly normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5tm2Dgi mutation
(1 available);
any
F5 mutation
(159 available)
Proztm1Gjb mutation
(0 available);
any
Proz mutation
(29 available)
|
|
|
mortality/aging
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• fewer (only 10% of expected 50%) animals of this genotype are found at 6 weeks
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5tm2Dgi mutation
(1 available);
any
F5 mutation
(159 available)
Proztm1Gjb mutation
(0 available);
any
Proz mutation
(29 available)
|
|
|
mortality/aging
|
• mortality of double homozygotes is high; only 1 animal reached adulthood (6 weeks)
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cardiovascular system
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• at E17.5-18.5, almost all mutants show signs of hemorrhage
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5tm2Dgi mutation
(1 available);
any
F5 mutation
(159 available)
Proztm1Gjb mutation
(0 available);
any
Proz mutation
(29 available)
|
|
|
mortality/aging
|
• fewer (37% of expected 50%) animals of this genotype are found at 6 weeks
|
homeostasis/metabolism