Phenotypes associated with this allele

• Allele Symbol: Pax6^Coop
• Allele Name: corneal opacity
• Allele ID: MGI:1931308
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax6^Coop/Pax6^Coop	C3.D2-Pax6^Coop	MGI:2175198
ht2	Pax6^Coop/Pax6^+	C3.D2-Pax6^Coop	MGI:2175199

Genotype
MGI:2175198

hm1

• Allelic Composition: Pax6^Coop/Pax6^Coop
• Genetic Background: C3.D2-Pax6^Coop

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:66649 )

respiratory system

absent external nares ( J:66649 )

• absence of nasal openings

vision/eye

anophthalmia ( J:66649 )

craniofacial

absent external nares ( J:66649 )

• absence of nasal openings

growth/size/body

absent external nares ( J:66649 )

• absence of nasal openings

Genotype
MGI:2175199

ht2

• Allelic Composition: Pax6^Coop/Pax6⁺
• Genetic Background: C3.D2-Pax6^Coop

vision/eye

abnormal iris morphology ( J:66649 )

• in less severe cases with corneal opacity, the iris had attachments to the lens

cornea opacity ( J:66649 )

• variable penetrance with vascularization of the cornea in severe cases

microphthalmia ( J:66649 )

• variable penetrance with triangular lens apetures in embryonic stages

• mean eye weights were reduced in heterozygous animals