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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pax6Coop
corneal opacity
MGI:1931308
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pax6Coop/Pax6Coop C3.D2-Pax6Coop MGI:2175198
ht2
 		Pax6Coop/Pax6+ C3.D2-Pax6Coop MGI:2175199


Genotype
MGI:2175198
hm1
Allelic
Composition		 Pax6Coop/Pax6Coop
Genetic
Background		 C3.D2-Pax6Coop
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6Coop mutation (0 available); any Pax6 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

respiratory system
absent external nares ( J:66649 )
• absence of nasal openings

vision/eye

craniofacial
absent external nares ( J:66649 )
• absence of nasal openings

growth/size/body
absent external nares ( J:66649 )
• absence of nasal openings




Genotype
MGI:2175199
ht2
Allelic
Composition		 Pax6Coop/Pax6+
Genetic
Background		 C3.D2-Pax6Coop
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6Coop mutation (0 available); any Pax6 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal iris morphology ( J:66649 )
• in less severe cases with corneal opacity, the iris had attachments to the lens
corneal opacity ( J:66649 )
• variable penetrance with vascularization of the cornea in severe cases
microphthalmia ( J:66649 )
• variable penetrance with triangular lens apetures in embryonic stages
• mean eye weights were reduced in heterozygous animals




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory