Phenotypes associated with this allele

• Allele Symbol: Egr2^tm1Grid
• Allele Name: targeted mutation 1, Tom Gridley
• Allele ID: MGI:1931057
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egr2^tm1Grid/Egr2^tm1Grid	involves: 129S1/Sv * C57BL/6J	MGI:2183217

Genotype
MGI:2183217

hm1

• Allelic Composition: Egr2^tm1Grid/Egr2^tm1Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:15577 )

• 70% of animals died within 24 hours of birth

postnatal lethality, complete penetrance ( J:15577 )

• the 30% surviving the first 24 hours after birth live for 5-10 days

growth/size/body

decreased body size ( J:15577 )

• severely runted compared to littermates

nervous system

absent rhombomere 3 ( J:15577 )

• absence of r3 in E9.0 embryos

absent rhombomere 5 ( J:15577 )

• absence of r5 in E9.0 embryos

abnormal cranial ganglia morphology ( J:15577 )

abnormal cochlear ganglion morphology ( J:15577 )

• less condensed than wild-type and overlapped with the trigeminal ganglion

abnormal trigeminal ganglion morphology ( J:15577 )

• less condensed than wild-type and overlapped with the facial/acoustic ganglion

abnormal cranial nerve morphology ( J:15577 )

fusion of glossopharyngeal and vagus nerve ( J:15577 )

embryo

absent rhombomere 3 ( J:15577 )

• absence of r3 in E9.0 embryos

absent rhombomere 5 ( J:15577 )

• absence of r5 in E9.0 embryos