Phenotypes associated with this allele

• Allele Symbol: Mgmt^tm1Lds
• Allele Name: targeted mutation 1, Leona D Samson
• Allele ID: MGI:1930999
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgmt^tm1Lds/Mgmt^tm1Lds	involves: 129P2/OlaHsd * C57BL/6	MGI:3700238

Genotype
MGI:3700238

hm1

• Allelic Composition: Mgmt^tm1Lds/Mgmt^tm1Lds
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:118148 )

• after SHDS treatment, levels are normal after 24 hours, but increase to >300 mg/dl in 48 hours in treated mutants and controls

increased susceptibility to injury ( J:118148 )

• mutants are more susceptible to alkylating agents; SHDS treatment induces bone marrow toxicity in mutants

endocrine/exocrine glands

small pancreatic islets ( J:118148 )

• islet size is decreased and insulin staining is almost absent after SHDS treatment