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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bdnftm2(Ntf5)Jae
targeted mutation 2, Rudolf Jaenisch
MGI:1929985
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae involves: 129S4/SvJae MGI:2175725
ht2
 		Bdnftm1Jae/Bdnftm2(Ntf5)Jae involves: 129S4/SvJae MGI:3583671
cx3
 		Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Ntrk2tm1Kln/Ntrk2tm1Kln 		involves: 129S4/SvJae MGI:3583672
cx4
 		Bdnftm1Jae/Bdnftm2(Ntf5)Jae
Ntrk2tm1Kln/Ntrk2tm1Kln 		involves: 129S4/SvJae MGI:3583673


Genotype
MGI:2175725
hm1
Allelic
Composition		 Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm2(Ntf5)Jae mutation (0 available); any Bdnf mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
excessive scratching ( J:61340 )
• especially of ears and neck

growth/size/body
decreased body weight ( J:61340 )
• 30% less than littermates at 2-6 months of age

nervous system
nervous system phenotype ( J:61340 )
N
• normal sensory ganglia

reproductive system




Genotype
MGI:3583671
ht2
Allelic
Composition		 Bdnftm1Jae/Bdnftm2(Ntf5)Jae
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Jae mutation (2 available); any Bdnf mutation (42 available)
Bdnftm2(Ntf5)Jae mutation (0 available); any Bdnf mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:61340 )
• mice are fertile and have a normal appearance




Genotype
MGI:3583672
cx3
Allelic
Composition		 Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm2(Ntf5)Jae mutation (0 available); any Bdnf mutation (42 available)
Ntrk2tm1Kln mutation (0 available); any Ntrk2 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:61340 )
• episodic




Genotype
MGI:3583673
cx4
Allelic
Composition		 Bdnftm1Jae/Bdnftm2(Ntf5)Jae
Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Jae mutation (2 available); any Bdnf mutation (42 available)
Bdnftm2(Ntf5)Jae mutation (0 available); any Bdnf mutation (42 available)
Ntrk2tm1Kln mutation (0 available); any Ntrk2 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

nervous system
decreased sensory neuron number ( J:61340 )
• observed in the vestibular, nodose-petrosal and geniculate ganglia




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory