Phenotypes associated with this allele

• Allele Symbol: Hgf^tm1Kita
• Allele Name: targeted mutation 1, Naomi Kitamura
• Allele ID: MGI:1929776
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hgf^tm1Kita/Hgf^tm1Kita	involves: 129S4/SvJae * C57BL/6	MGI:2175065
cx2	Cd44^tm1Mak/Cd44^tm1Mak Hgf^tm1Kita/Hgf^+	involves: 129S4/SvJae * C57BL/6	MGI:4946523

Genotype
MGI:2175065

hm1

• Allelic Composition: Hgf^tm1Kita/Hgf^tm1Kita
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:23171 )

• no live embryos recovered after E15.5

embryo

abnormal placental labyrinth vasculature morphology ( J:23171 )

• the network of embryonic vessels and maternal sinuses is poorly developed

decreased embryo size ( J:23171 )

• slightly smaller size

decreased trophoblast giant cell number ( J:23171 )

• reduced cell number resulted in a reduced size of the labyrinth region

• first detectable at E10.5 and fully apparent by E11.5

small placenta ( J:23171 )

• at E13.5, placentas appear small and pale compared to controls

liver/biliary system

small liver ( J:23171 )

• no histological abnormalities are seen despite small size

growth/size/body

decreased embryo size ( J:23171 )

• slightly smaller size

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:23171 )

• the network of embryonic vessels and maternal sinuses is poorly developed

Genotype
MGI:4946523

cx2

• Allelic Composition: Cd44^tm1Mak/Cd44^tm1Mak; Hgf^tm1Kita/Hgf⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

mortality/aging

neonatal lethality, incomplete penetrance ( J:128984 )

• shortly after birth, 69% of the animals die