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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Erbb3+
wild type
MGI:1929626
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Erbb2tm1Cbm/Erbb2+
Erbb3tm2Cbm/Erbb3+
Nrg1tm1Cbm/Nrg1+ 		involves: 129P2/OlaHsd MGI:3530779
cx2
 		Erbb3tm1.1(ERBB3)Mul/Erbb3+
Tg(MMTV-Erbb2*)NDL2-5Mul/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5447010


Genotype
MGI:3530779
cx1
Allelic
Composition		 Erbb2tm1Cbm/Erbb2+
Erbb3tm2Cbm/Erbb3+
Nrg1tm1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Cbm mutation (0 available); any Erbb2 mutation (57 available)
Erbb3tm2Cbm mutation (0 available); any Erbb3 mutation (44 available)
Nrg1tm1Cbm mutation (0 available); any Nrg1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:90038 )
• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age
abnormal nerve conduction ( J:90038 )
• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials




Genotype
MGI:5447010
cx2
Allelic
Composition		 Erbb3tm1.1(ERBB3)Mul/Erbb3+
Tg(MMTV-Erbb2*)NDL2-5Mul/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3tm1.1(ERBB3)Mul mutation (0 available); any Erbb3 mutation (44 available)
Tg(MMTV-Erbb2*)NDL2-5Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor latency ( J:189292 )
• intermediate compared to in Tg(MMTV-Erbb2*)NDL2-5Mul mice

integument

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory