Phenotypes associated with this allele

• Allele Symbol: Musk^tm1Gdy
• Allele Name: targeted mutation 1, George D Yancopoulos
• Allele ID: MGI:1929066
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Musk^tm1Gdy/Musk^tm1Gdy	involves: 129P2/OlaHsd * C57BL/6	MGI:3029329

Genotype
MGI:3029329

hm1

• Allelic Composition: Musk^tm1Gdy/Musk^tm1Gdy
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:33132 )

• animals die shortly after birth

behavior/neurological

unresponsive to tactile stimuli ( J:33132 )

no spontaneous movement ( J:33132 )

homeostasis/metabolism

cyanosis ( J:33132 )

respiratory system

respiratory failure ( J:33132 )

• animals fail to breathe

nervous system

abnormal innervation pattern to muscle ( J:33132 )

• neurons grow past typical target endplate site and extend to myotendenous ends of muscle

abnormal motor neuron innervation pattern ( J:33132 )

• neurons grow past typical target endplate site and extend to myotendenous ends of muscle

abnormal neuromuscular synapse morphology ( J:33132 )

• synapses do not form

failure of neuromuscular synapse postsynaptic differentiation ( J:33132 )

failure of neuromuscular synapse presynaptic differentiation ( J:33132 )