Phenotypes associated with this allele

• Allele Symbol: Grin2c^tm1Rsp
• Allele Name: targeted mutation 1, Rolf Sprengel
• Allele ID: MGI:1928514
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2c^tm1Rsp/Grin2c^tm1Rsp	involves: 129S1/Sv * 129X1/SvJ	MGI:3847252
cx2	Grin2a^tm1Rsp/Grin2a^tm1Rsp Grin2c^tm1Rsp/Grin2c^tm1Rsp	involves: 129S1/Sv * 129X1/SvJ	MGI:3850691

Genotype
MGI:3847252

hm1

• Allelic Composition: Grin2c^tm1Rsp/Grin2c^tm1Rsp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired balance ( J:45446 )

• impaired balance is shown by a decreased retention time on a thin stationary plexiglass rod

• retention times on a rotarod is similar to controls

Genotype
MGI:3850691

cx2

• Allelic Composition: Grin2a^tm1Rsp/Grin2a^tm1Rsp; Grin2c^tm1Rsp/Grin2c^tm1Rsp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

behavior/neurological

impaired contextual conditioning behavior ( J:45446 )

• mice exhibit reduced latency in the step-down avoidance task; these mice all exhibit jumping and vocalization upon shock, suggesting that this phenotype is not attributable to differences in pain perception

impaired coordination ( J:45446 )

• impaired motor coordination is shown by a decreased retention time on a rotarod and on a thin stationary plexiglass rod

nervous system

nervous system phenotype ( J:45446 )

N • mutant mice exhibit slightly reduced cerebellar NR1 levels, but comimmunoprecipitation experiments show that the NR1 and mutant subunits are associated with each other as well as with PSD-95

N • synaptic activation of these mutant receptors evoked postsynaptic elevations of Ca2+ intracellular concentration, similar to the controls