Phenotypes associated with this allele

• Allele Symbol: Grin2b^tm1Rsp
• Allele Name: targeted mutation 1, Rolf Sprengel
• Allele ID: MGI:1928293
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2b^tm1Rsp/Grin2b^tm1Rsp	involves: 129S1/Sv * 129X1/SvJ	MGI:3847251
ht2	Grin2b^tm1Rsp/Grin2b^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5505867

Genotype
MGI:3847251

hm1

• Allelic Composition: Grin2b^tm1Rsp/Grin2b^tm1Rsp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:45446 )

• homozygous mice dise shortly after birth

nervous system

abnormal NMDA-mediated synaptic currents ( J:45446 )

• in hippocampus slices from newborn homozygous mice, desensitization occurs in the presence of NMDA; however, the evoked current amplitudes are about half that of control mice

Genotype
MGI:5505867

ht2

• Allelic Composition: Grin2b^tm1Rsp/Grin2b⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

behavior/neurological

decreased anxiety-related response ( J:197485 )

• in an open field, mice travel more distance compared with wild-type mice

impaired coordination ( J:197485 )

nervous system

reduced long-term potentiation ( J:197485 )

• following theta burst stimulation