Phenotypes associated with this allele

• Allele Symbol: Myf6^tm1Thbr
• Allele Name: targeted mutation 1, Thomas Braun
• Allele ID: MGI:1927607
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf6^tm1Thbr/Myf6^tm1Thbr	either: (involves: 129S4/SvJae-Myf6^tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:2175129
cx2	Myf5^tm1Jae/Myf5^+ Myf6^tm1Thbr/Myf6^+	involves: 129S4/SvJae	MGI:3714395

Genotype
MGI:2175129

hm1

• Allelic Composition: Myf6^tm1Thbr/Myf6^tm1Thbr
• Genetic Background: either: (involves: 129S4/SvJae-Myf6^tm1Thbr) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:24360 )

• die within a few minutes after birth

embryo

abnormal somite development ( J:24360 )

• embryos show a lack of primary myocytes in somites between E9.5 and E10.5

skeleton

abnormal sternocostal joint morphology ( J:24360 )

• lack the distal parts of the ribs and thus no contacts with the sternum are made

abnormal sternum ossification ( J:24360 )

• sternum is completely ossified

abnormal rib morphology ( J:24360 )

short ribs ( J:24360 , J:31636 )

• lack the distal parts of the ribs (J:24360)

• ribs are shorter than in wild-type but are somewhat longer than in Myf5^tm1Jae mice (J:31636)

muscle

abnormal muscle morphology ( J:24360 )

• significant decrease in muscle fibers of the deep axial muscles at several locations along the rostro-caudal axis (the deep back muscles)

Genotype
MGI:3714395

cx2

• Allelic Composition: Myf5^tm1Jae/Myf5⁺; Myf6^tm1Thbr/Myf6⁺
• Genetic Background: involves: 129S4/SvJae

mortality/aging

perinatal lethality, complete penetrance ( J:31636 )

• double heterozygous mice that carry the Myf5 and Myf6 alleles on different chromosomes and express drastically reduced levels of Myf5 mRNA do not survive to weaning and when delivered by cesarean section at E18.5, the pups die within a few minutes after delivery

skeleton

short ribs ( J:31636 )

• mutants lack the distal parts of the ribs

• the average rib length is between that of Myf6 and Myf5 homozygotes