About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd74tm1Eae
targeted mutation 1, Eileen A Elliott
MGI:1927544
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd74tm1Eae/Cd74tm1Eae B6.129S2-Cd74tm1Eae MGI:4867046
hm2
 		Cd74tm1Eae/Cd74tm1Eae involves: 129S2/SvPas MGI:3842543
hm3
 		Cd74tm1Eae/Cd74tm1Eae involves: 129S2/SvPas * C57BL/6 MGI:6705078


Genotype
MGI:4867046
hm1
Allelic
Composition		 Cd74tm1Eae/Cd74tm1Eae
Genetic
Background		 B6.129S2-Cd74tm1Eae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Eae mutation (0 available); any Cd74 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested B cell differentiation ( J:112084 )
• arrest at the immature B cell stage
abnormal lymph node cell ratio ( J:112084 )
• striking decrease in the proportion of B cells in the lymph nodes

hematopoietic system
arrested B cell differentiation ( J:112084 )
• arrest at the immature B cell stage




Genotype
MGI:3842543
hm2
Allelic
Composition		 Cd74tm1Eae/Cd74tm1Eae
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Eae mutation (0 available); any Cd74 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:113050 , J:132865 )
• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)
• following anti-CD74 stimulation (J:132865)
decreased IgM level ( J:113050 )
• in response to NP immunization
abnormal level of surface class II molecules ( J:65917 )
• cell surface expression of class II molecules in splenocytes is decreased compared to in wild-type cells

cellular
decreased cell proliferation ( J:147772 )
• mouse embryonic fibroblasts transformed retrovirally with Ras produce fewer and smaller colonies than similarly treated wild-type cells
decreased B cell proliferation ( J:113050 , J:132865 )
• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)
• following anti-CD74 stimulation (J:132865)

hematopoietic system
decreased B cell proliferation ( J:113050 , J:132865 )
• B cell proliferation in response to NP-Ficoll and NP-CGG is decreased compared to in wild-type cells (J:113050)
• following anti-CD74 stimulation (J:132865)
decreased IgM level ( J:113050 )
• in response to NP immunization




Genotype
MGI:6705078
hm3
Allelic
Composition		 Cd74tm1Eae/Cd74tm1Eae
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74tm1Eae mutation (0 available); any Cd74 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased susceptibility to myocardial ischemic injury ( J:213776 )
• left ventricle contractile dysfunction is more pronounced and myocardial necrosis is 2-fold more pronounced in isolated perfused hearts during reperfusion after ischemia than in homozygous Miftm1Dvd or wild-type hearts
increased myocardial infarct size ( J:213776 )
• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in homozygous Miftm1Dvd or wild-type hearts

homeostasis/metabolism
increased susceptibility to myocardial ischemic injury ( J:213776 )
• left ventricle contractile dysfunction is more pronounced and myocardial necrosis is 2-fold more pronounced in isolated perfused hearts during reperfusion after ischemia than in homozygous Miftm1Dvd or wild-type hearts
increased myocardial infarct size ( J:213776 )
• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in homozygous Miftm1Dvd or wild-type hearts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory