Phenotypes associated with this allele

• Allele Symbol: Tg(KRT14-PTHLH)7Wmp
• Allele Name: transgene insertion 7, William M Philbrick
• Allele ID: MGI:1926698
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHLH)2Ecw/0 Tg(KRT14-PTHLH)7Wmp/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3717420
tg2	Tg(KRT14-PTHLH)7Wmp/0	Not Specified	MGI:2174880

Genotype
MGI:3717420

cx1

• Allelic Composition: Pthlh^tm1Hmk/Pthlh^tm1Hmk; Tg(Col2a1-PTHLH)2Ecw/0; Tg(KRT14-PTHLH)7Wmp/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dental phenotype of Pthlh^tm1Hmk/Pthlh^tm1Hmk mice rescued with Tg(Col2a1-PTHLH)2Ecw and Tg(KRT14-PTHLH)7Wmp transgenes

mortality/aging

premature death ( J:50144 )

growth/size/body

long lower incisors ( J:50144 )

• malocclusion allows for unchecked growth of the lower incisors

malocclusion ( J:50144 )

• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors

• upper incisors remain partly occluded and are less affected

• however, incisors and molars erupt normally and on schedule

short maxilla ( J:50144 )

• foreshortened maxilla

decreased body size ( J:50144 )

decreased body weight ( J:50144 )

skeleton

long lower incisors ( J:50144 )

• malocclusion allows for unchecked growth of the lower incisors

malocclusion ( J:50144 )

• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors

• upper incisors remain partly occluded and are less affected

• however, incisors and molars erupt normally and on schedule

short maxilla ( J:50144 )

• foreshortened maxilla

chondrodystrophy ( J:50144 )

• develop progressive chondrodystrophy

craniofacial

long lower incisors ( J:50144 )

• malocclusion allows for unchecked growth of the lower incisors

malocclusion ( J:50144 )

• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors

• upper incisors remain partly occluded and are less affected

• however, incisors and molars erupt normally and on schedule

short maxilla ( J:50144 )

• foreshortened maxilla

Genotype
MGI:2174880

tg2

• Allelic Composition: Tg(KRT14-PTHLH)7Wmp/0
• Genetic Background: Not Specified

adipose tissue

decreased subcutaneous adipose tissue amount ( J:65043 )

• very little fat is present in the subcutis

integument

decreased subcutaneous adipose tissue amount ( J:65043 )

• very little fat is present in the subcutis

abnormal auchene hair morphology ( J:65043 )

• the relative frequency of the auchene hairs is reduced

abnormal awl hair morphology ( J:65043 )

• the relative frequency of the awl hairs is reduced

abnormal hair growth ( J:65043 )

focal ventral hair loss ( J:65043 )

• by 6 days of age, mutants exhibit ventral hairlessness that extends the length of the body and to the midaxillary lines bilaterally

• males are less severely affected and show some ventral hair growth in two paramedial strips

short hair ( J:65043 )

• all hair types are present but are shorter

sparse hair ( J:65043 )

• dorsal coat is thinner and is deficient in overhairs, the long hairs that protrude beyond the general coat

thin hair shaft ( J:65043 )

• all hair types are present but are thinner

abnormal hair follicle morphology ( J:65043 )

• hair follicles are almost completely absent in the ventral skin

abnormal hair follicle development ( J:65043 )

• fail to initiate follicle development in the ventral skin, leading to absence of hair follicles

• show a delay in the initiation of hair follicles and eruption of hair on the dorsal skin

decreased hair follicle number ( J:65043 )

• a somewhat lower density of hair follicles occurs dorsally, with a selective decrease in the larger and more deeply penetrating follicles

abnormal dermal layer morphology ( J:65043 )

• the ventral dermis is expanded

hyperkeratosis ( J:65043 )

• mild hyperkeratosis in the ventral epidermis and ear epidermis

thick epidermis ( J:65043 )

• the ventral epidermis and the epidermis of the ear are thickened

abnormal tail ring morphology ( J:65043 )

• tail skin shows an effacement of the alternating ridge-like epidermal pattern

thin skin ( J:65043 )

• overall thickness of the skin is reduced due to the decreased amount of fat in the subcutis