Phenotypes associated with this allele

• Allele Symbol: Gfra2^tm1Msa
• Allele Name: targeted mutation 1, Matti S Airaksinen
• Allele ID: MGI:1926440
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfra2^tm1Msa/Gfra2^tm1Msa	either: B6.129-Gfra2^tm1Msa or 129S2.129-Gfra2^tm1Msa	MGI:3582983
hm2	Gfra2^tm1Msa/Gfra2^tm1Msa	either: (involves: 129S1/Sv * 129S2/SvHsd * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6NHsd)	MGI:3582982
hm3	Gfra2^tm1Msa/Gfra2^tm1Msa	involves: 129S1/Sv * 129X1/SvJ	MGI:3654033

Genotype
MGI:3582983

hm1

• Allelic Composition: Gfra2^tm1Msa/Gfra2^tm1Msa
• Genetic Background: either: B6.129-Gfra2^tm1Msa or 129S2.129-Gfra2^tm1Msa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased gonadal fat pad weight ( J:93911 )

• weight reduced by 40%

behavior/neurological

increased fluid intake ( J:93911 )

• increased water intake

increased food intake ( J:93911 )

• slight but significant increase in food intake

digestive/alimentary system

intestinal hypoperistalsis ( J:93911 )

• motility of the small intestine is reduced

homeostasis/metabolism

increased basal metabolism ( J:93911 )

• basal metabolic rate was increased

muscle

intestinal hypoperistalsis ( J:93911 )

• motility of the small intestine is reduced

Genotype
MGI:3582982

hm2

• Allelic Composition: Gfra2^tm1Msa/Gfra2^tm1Msa
• Genetic Background: either: (involves: 129S1/Sv * 129S2/SvHsd * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6NHsd)

behavior/neurological

decreased kindling response ( J:53284 )

• suppressed development and persistence of kindling epilepsy

growth/size/body

decreased body weight ( J:53284 )

nervous system

decreased kindling response ( J:53284 )

• suppressed development and persistence of kindling epilepsy

small submandibular ganglion ( J:53284 )

abnormal parasympathetic postganglionic fiber morphology ( J:53284 )

• absent projections to the lacrimal gland, parotid gland and the sublingual gland

vision/eye

blepharoptosis ( J:53284 )

dry eyes ( J:53284 )

integument

accelerated hair follicle regression ( J:53284 )

Genotype
MGI:3654033

hm3

• Allelic Composition: Gfra2^tm1Msa/Gfra2^tm1Msa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

integument

accelerated hair follicle regression ( J:65034 )

• exhibit accelerated catagen development, such that at P17, most hair follicles are already in late catagen rather than at the beginning of catagen

thin skin ( J:65034 )

• seen at P17