Phenotypes associated with this allele

• Allele Symbol: Cdx2^tm1Mmt
• Allele Name: targeted mutation 1, Makoto M Taketo
• Allele ID: MGI:1926374
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdx2^tm1Mmt/Cdx2^tm1Mmt	involves: 129X1/SvJ * C57BL/6	MGI:2175779
ht2	Cdx2^tm1Mmt/Cdx2^+	B6.129X1-Cdx2^tm1Mmt	MGI:3715019
ht3	Cdx2^tm1Mmt/Cdx2^+	involves: 129X1/SvJ * C57BL/6	MGI:3715018
cx4	Cdx2^tm1Mmt/Cdx2^+ Apc^tm1Mmt/Apc^+	B6.129-Cdx2^tm1Mmt Apc^tm1Mmt	MGI:3715020

Genotype
MGI:2175779

hm1

• Allelic Composition: Cdx2^tm1Mmt/Cdx2^tm1Mmt
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:47050 )

• no homozygous embryos by E7.5

embryo

absent inner cell mass proliferation ( J:47050 )

• no proliferation of inner cell mass in culture although trophectoderm outgrowth is normal

cellular

absent inner cell mass proliferation ( J:47050 )

• no proliferation of inner cell mass in culture although trophectoderm outgrowth is normal

Genotype
MGI:3715019

ht2

• Allelic Composition: Cdx2^tm1Mmt/Cdx2⁺
• Genetic Background: B6.129X1-Cdx2^tm1Mmt

digestive/alimentary system

abnormal colon morphology ( J:86737 )

• moderately increased anaphase bridge index

• accelerated transition from G1 to S phase

• increased DNA synthesis

• lower apoptotic rates

abnormal small intestine morphology ( J:86737 )

• moderately decreased anaphase bridge index

• decreased transition from G1 to S phase

• decreased DNA synthesis

• increased apoptotic rates

cellular

abnormal chromosome morphology ( J:86737 )

• moderately increased anaphase bridge index in the large intestine and decreased in the small intestine

abnormal cell cycle checkpoint function ( J:86737 )

• accelerated transition from G1 to S phase in the large intestine and decreased in the small intestine

• increased DNA synthesis in the large intestine and decreased in the small intestine

decreased apoptosis ( J:86737 )

• lower apoptotic rates in the large intestine

increased apoptosis ( J:86737 )

• in the small intestine

Genotype
MGI:3715018

ht3

• Allelic Composition: Cdx2^tm1Mmt/Cdx2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

growth/size/body

decreased body size ( J:47050 )

• runted

skeleton

abnormal rib morphology ( J:47050 )

• malformed

vertebral transformation ( J:47050 )

• anterior homeotic shift of vertebrae

digestive/alimentary system

abnormal cecum morphology ( J:47050 )

• numerous viliform structures aligned in rows

• epithelium containing enterocytes and a few goblet cells

• anteriorization of epithelium

abnormal colon morphology ( J:47050 )

• numerous viliform structures aligned in rows

• villi are structurally similar to those in ileum but extending from colonic type crypts

• epithelium containing enterocytes and a few goblet cells

• anteriorization of epithelium

colon polyps ( J:47050 )

• in proximal colon

• benign in nature

• up to 8 mm in diameter

• up to 10/mouse at 3 months of age

increased colon hamartoma incidence ( J:47050 )

• colonic polyps similar to hamartomas but lacking goblet or paneth cells

neoplasm

increased colon hamartoma incidence ( J:47050 )

• colonic polyps similar to hamartomas but lacking goblet or paneth cells

Genotype
MGI:3715020

cx4

• Allelic Composition: Cdx2^tm1Mmt/Cdx2⁺; Apc^tm1Mmt/Apc⁺
• Genetic Background: B6.129-Cdx2^tm1Mmt Apc^tm1Mmt

digestive/alimentary system

abnormal colon morphology ( J:86737 )

• increased anaphase bridge index

• accelerated transition from G1 to S phase

• increased DNA synthesis

• lower apoptotic rates

colon polyps ( J:86737 )

• increased in numbers relative to Apc^tm1Mmt

• mostly in the distal colon

abnormal small intestine morphology ( J:86737 )

• decreased anaphase bridge index

• decreased transition from G1 to S phase

• decreased DNA synthesis

• increased apoptotic rates

• significantly reduced number of polyps relative to Apc^tm1Mmt

cellular

abnormal chromosome morphology ( J:86737 )

• increased anaphase bridge index in the large intestine and decreased in the small intestine

abnormal cell cycle checkpoint function ( J:86737 )

• accelerated transition from G1 to S phase in the large intestine and decreased in the small intestine

• increased DNA synthesis in the large intestine and decreased in the small intestine

decreased apoptosis ( J:86737 )

• lower apoptotic rates in the large intestine

increased apoptosis ( J:86737 )

• in the small intestine