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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf7tm2Cle
targeted mutation 2, Hans Clevers
MGI:1926299
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf7tm2Cle/Tcf7tm2Cle involves: 129P2/OlaHsd MGI:2174760


Genotype
MGI:2174760
hm1
Allelic
Composition		 Tcf7tm2Cle/Tcf7tm2Cle
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7tm2Cle mutation (0 available); any Tcf7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:23255 )
• thymus cellularity is reduced 2- to a 5- fold compared to controls
decreased double-positive T cell number ( J:23255 )
• absolute numbers of double-positive thymocytes are reduced 3- to 5- fold compared to controls
decreased single-positive T cell number ( J:23255 )
• absolute numbers of single-positive thymocytes are reduced 3- to 5- fold compared to controls

hematopoietic system
thymus hypoplasia ( J:23255 )
• thymus cellularity is reduced 2- to a 5- fold compared to controls
decreased double-positive T cell number ( J:23255 )
• absolute numbers of double-positive thymocytes are reduced 3- to 5- fold compared to controls
decreased single-positive T cell number ( J:23255 )
• absolute numbers of single-positive thymocytes are reduced 3- to 5- fold compared to controls

endocrine/exocrine glands
thymus hypoplasia ( J:23255 )
• thymus cellularity is reduced 2- to a 5- fold compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory