Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf7tm1Efu mutation
(1 available);
any
Fgf7 mutation
(17 available)
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behavior/neurological
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• pentylenetetrazol-treated mice develop major seizures sooner than similarly treated wild-type mice
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nervous system
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• pentylenetetrazol-treated mice develop major seizures sooner than similarly treated wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf7tm1Efu mutation
(1 available);
any
Fgf7 mutation
(17 available)
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nervous system
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• at symmetric synapses, synaptic vesicles are smaller than in wild-type mice
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• fewer vesicles are docked at symmetric synapses compared to in wild-type mice
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• at P14, vesicle clustering in GABAergic synapses is decreased in the CA3 compared to in wild-type mice
• CA3 pyramidal neurons cultured for 14 days have fewer GABAergic vesicles associated with dendrites compared to in cultured wild-type neurons
• however, vesicle clustering in glutamatergic synapses is normal
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• the frequency of miniature inhibitory postsynaptic currents (mIPSCs) is decreased compared to in wild-type hippocampal cultures
• however, the amplitude of mIPSCs is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf7tm1Efu mutation
(1 available);
any
Fgf7 mutation
(17 available)
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renal/urinary system
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• epithelium of collecting ducts is low cuboid rather than high cuboid or columnar
• functionally normal
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• fewer papillary collecting ducts
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• normal from E11.5 to E13.5, after 3-4 rounds of branching
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• few ureteric bud branches in the inner medullary region at E16.5
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• kidneys are small while body size is normal
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• 30% reduction in the number of nephrons but density normal
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• few ureteric bud branches in the inner medullary region at E16.5
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homeostasis/metabolism
reproductive system
N |
• testes and seminal vesicles are normal
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hematopoietic system
N |
• peripheral lymph nodes show no difference in cellularity or T-cell distribution relative to controls
• bone marrow has similar numbers of hematopoietic precursors as in wild-type
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• cellularity is reduced compared to wild-type and heterozygous controls with lower absolute numbers of T cells, B cells and dendritic cells
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immune system
N |
• thymopoeisis and T-cell development are normal in mutants
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• cellularity is reduced compared to wild-type and heterozygous controls with lower absolute numbers of T cells, B cells and dendritic cells
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• after sublethal irradiation, thymic cellularity and thymic subpopulations are significantly lower than in controls at 21 and 28 days after irradiation indicating defective thymic recovery
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• irradiated mice transplanted with allogeneic bone marrow from wild-type mice have decreased numbers of host- and donor-derived T cells compared to wild-type
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integument
N |
• no major abnormalities in hair structure or hair types
• hair lengths normal
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• perturbation in the direction of hairs within the coat
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• by 2 months in males
• by 1 year in females
• phenotype becomes more prominent with age
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• no excess of oil or greasy substances
• by 2 months in males
• by 1 year in females
• phenotype becomes more prominent with age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf5tm1Tzi mutation
(0 available);
any
Fgf5 mutation
(14 available)
Fgf6tm1Thbr mutation
(0 available);
any
Fgf6 mutation
(7 available)
Fgf7tm1Efu mutation
(1 available);
any
Fgf7 mutation
(17 available)
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integument
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• hair length is increased compared to Fgf5tm1Tzi homozygotes
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