All Phenotypes Aqp11<sjds> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aqp11^sjds/Aqp11^sjds	involves: BALB/cRl	MGI:4941787
hm2	Aqp11^sjds/Aqp11^sjds	involves: BALB/cRl * C3H/Rl * C57BL/10Rl	MGI:2449617
ht3	Aqp11^sjds/Aqp11^tm1Lex	involves: 129S5/SvEvBrd * BALB/cRl * C57BL/6 * CD-1	MGI:4941788

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:169660 )

• all mice die by P20

renal/urinary system

decreased urine osmolality ( J:169660 )

abnormal kidney cortex morphology ( J:169660 )

• mice exhibit tubular and cellular swelling with the formation of giant vacuoles ("spider web") in the renal cortex unlike wild-type mice

abnormal renal tubule morphology ( J:169660 )

• mice exhibit tubular swelling unlike wild-type mice

• mice exhibit alterations in the tubular membrane consistent with severe epithelial cell injury unlike wild-type mice

abnormal renal tubule epithelium morphology ( J:169660 )

• mice exhibit alterations in the tubular membrane consistent with severe epithelial cell injury unlike wild-type mice

abnormal proximal convoluted tubule morphology ( J:169660 )

• mice exhibit altered proximal tubule epithelial cells including destruction of the brush border and disorganization of the mitochondrial matrix unlike wild-type mice

proximal convoluted tubule brush border loss ( J:169660 )

• destruction of the brush border

pale kidney ( J:169660 )

kidney failure ( J:169660 )

homeostasis/metabolism

increased circulating creatinine level ( J:169660 )

increased blood urea nitrogen level ( J:169660 )

• 4.7-fold

decreased urine osmolality ( J:169660 )

growth/size/body

decreased body weight ( J:169660 )

• at weaning

Allelic Composition	Aqp11^sjds/Aqp11^sjds
Genetic Background	involves: BALB/cRl * C3H/Rl * C57BL/10Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp11^sjds mutation (0 available); any Aqp11 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:54592 )

• animals are described as dying suddenly between 2 and 3 weeks of age; appear healthy until this time

Allelic Composition	Aqp11^sjds/Aqp11^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * BALB/cRl * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp11^sjds mutation (0 available); any Aqp11 mutation (16 available)
Aqp11^tm1Lex mutation (1 available); any Aqp11 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:169660 )

• mice die between 10 and 20 days

renal/urinary system

abnormal kidney cortex morphology ( J:169660 )

• mice exhibit tubular and cellular swelling with the formation of giant vacuoles ("spider web") in the renal cortex unlike wild-type mice

abnormal renal tubule morphology ( J:169660 )

• mice exhibit tubular swelling unlike wild-type mice

• mice exhibit alterations in the tubular membrane consistent with severe epithelial cell injury unlike wild-type mice

pale kidney ( J:169660 )

homeostasis/metabolism

increased blood urea nitrogen level ( J:169660 )

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