Phenotypes associated with this allele

• Allele Symbol: Fut7^tm1Brs
• Allele Name: targeted mutation 1, Brian Seed
• Allele ID: MGI:1888982
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fut7^tm1Brs/Fut7^tm1Brs	involves: 129 * C57BL/6	MGI:3783585

Genotype
MGI:3783585

hm1

• Allelic Composition: Fut7^tm1Brs/Fut7^tm1Brs
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:64232 )

N • susceptibility to indomethacin-induced changes in mucosa permeability is significantly attenuated relative to wild-type controls or Rag2-deficient mice

abnormal intestinal mucosa morphology ( J:64232 )

• when given 10-20 mg/kg indomethacin, mice have markedly less damage to integrity of the small bowel mucosa than controls or Rag2-null mice which develop small nonhemorrhagic lesions in the jejunum

abnormal stomach mucosa morphology ( J:64232 )

• when given 10-20 mg/kg indomethacin, mice have markedly less damage to integrity of the gastric mucosa than controls or Rag2-null mice which develop extensive hemorrhagic lesions of the gastric mucosa

immune system

immune system phenotype ( J:64232 )

N • mice develop minimal inflammation in response to indomethacin treatement compared to wild-type controls or Rag2-null animals