Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr1tm1Scp mutation
(1 available);
any
Ackr1 mutation
(22 available)
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homeostasis/metabolism
immune system
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• after incubation of the citrated blood, plasma concentrations of CXCL1 and CXCL5 are increased compared to in the plasma of similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr1tm1Scp mutation
(1 available);
any
Ackr1 mutation
(22 available)
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immune system
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• homozygotes are viable, fertile, and apparently healthy up to 1 year of age, with normal hematologic profiles relative to wild-type mice
• however, at 2 hrs after i.p. injection of LPS (30 mg/kg), homozygotes display an exaggerated inflammatory response with a significantly increased accumulation of leukocytes and neutrophils in lung and liver
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr1tm1Scp mutation
(1 available);
any
Ackr1 mutation
(22 available)
Cxcl5tm1Gscw mutation
(0 available);
any
Cxcl5 mutation
(10 available)
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homeostasis/metabolism
immune system
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• mice exhibit increased chemokine scavenging compared with wild-type mice although not as severe as in Darctm1Scp homozygotes
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Analysis Tools