Phenotypes associated with this allele

• Allele Symbol: Lsp1^tm1Jejb
• Allele Name: targeted mutation 1, Jenny Jongstra-Bilen
• Allele ID: MGI:1888973
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lsp1^tm1Jejb/Lsp1^tm1Jejb	involves: 129S1/Sv * 129X1/SvJ	MGI:3581981

Genotype
MGI:3581981

hm1

• Allelic Composition: Lsp1^tm1Jejb/Lsp1^tm1Jejb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte physiology ( J:68128 )

impaired neutrophil chemotaxis ( J:68128 )

• reduced mobility of neutrophils in chemotaxis

• large lamellopodia formed normally by neutrophiles in chemotaxis were absent and neutrophils are unable to move along a chemotactic gradient

abnormal cellular extravasation ( J:96022 )

• reduced ability of leukocytes to emigrate in response to inflammatory stimuli

abnormal immune system morphology ( J:64219 )

abnormal lymphopoiesis ( J:64219 )

• reduced numbers of small lymphocytes in the peritoneum

increased macrophage cell number ( J:64219 )

• expanded numbers of macrophage in the peritoneum

hematopoietic system

abnormal lymphopoiesis ( J:64219 )

• reduced numbers of small lymphocytes in the peritoneum

increased macrophage cell number ( J:64219 )

• expanded numbers of macrophage in the peritoneum

abnormal leukocyte physiology ( J:68128 )

impaired neutrophil chemotaxis ( J:68128 )

• reduced mobility of neutrophils in chemotaxis

• large lamellopodia formed normally by neutrophiles in chemotaxis were absent and neutrophils are unable to move along a chemotactic gradient

abnormal cellular extravasation ( J:96022 )

• reduced ability of leukocytes to emigrate in response to inflammatory stimuli

cellular

impaired neutrophil chemotaxis ( J:68128 )

• reduced mobility of neutrophils in chemotaxis

• large lamellopodia formed normally by neutrophiles in chemotaxis were absent and neutrophils are unable to move along a chemotactic gradient

abnormal cellular extravasation ( J:96022 )

• reduced ability of leukocytes to emigrate in response to inflammatory stimuli