All Phenotypes Lhx9<tm1Lmgd> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lhx9^tm1Lmgd
targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI:1888554

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lhx9^tm1Lmgd/Lhx9^tm1Lmgd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2181825

Allelic Composition	Lhx9^tm1Lmgd/Lhx9^tm1Lmgd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx9^tm1Lmgd mutation (2 available); any Lhx9 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

agonadal ( J:60621 )

• all mice lacked gonads; at E13.5, no gonads are apparent

absent ovary ( J:60621 )

absent testes ( J:60621 )

homeostasis/metabolism

decreased circulating testosterone level ( J:60621 )

• undetectable levels of testosterone

decreased circulating estradiol level ( J:60621 )

• undetectable levels of estradiol

increased circulating follicle stimulating hormone level ( J:60621 )

• elevated levels of FSH

reproductive system

decreased primordial germ cell proliferation ( J:60621 )

• primordial germ cells migrate to the gonadal region at E12.0, but the proliferation of gonadal cells at E11.5 was not apparent

abnormal female reproductive system morphology ( J:60621 )

• atrophic

uterus atrophy ( J:60621 )

vagina atrophy ( J:60621 )

abnormal male reproductive system morphology ( J:60621 )

• no male accessory sex organs found in genetically identified males

abnormal primary sex determination ( J:60621 )

• all mice phenotypically female, although half were genetically male

agonadal ( J:60621 )

• all mice lacked gonads; at E13.5, no gonads are apparent

absent ovary ( J:60621 )

absent testes ( J:60621 )

secondary sex reversal ( J:60621 )

• all mice phenotypically female, although half were genetically male

• no male accessory sex organs found in genetically identified males

absent estrous cycle ( J:60621 )

• females did not undergo an oestrus cycle

infertility ( J:60621 )

• mice were infertile

female infertility ( J:60621 )

male infertility ( J:60621 )

cellular

decreased primordial germ cell proliferation ( J:60621 )

• primordial germ cells migrate to the gonadal region at E12.0, but the proliferation of gonadal cells at E11.5 was not apparent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24