Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pecam1Gt(OST16303)Lex mutation
(1 available);
any
Pecam1 mutation
(227 available)
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cardiovascular system
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• unlike in wild-type mice, vessel dilation is not reduced by L-NAME
• however, treatment with A23187 (an agonist that stimulates Nos3) restores sensitivity to L-NAME
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• flow mediated dilation of arterioles is reduced compared to in wild-type mice
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muscle
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• unlike in wild-type mice, vessel dilation is not reduced by L-NAME
• however, treatment with A23187 (an agonist that stimulates Nos3) restores sensitivity to L-NAME
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• flow mediated dilation of arterioles is reduced compared to in wild-type mice
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pecam1Gt(OST16303)Lex mutation
(1 available);
any
Pecam1 mutation
(227 available)
|
|
|
cardiovascular system
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• flow mediated dilation of the coronary artery is reduced compared to in wild-type mice
• a slightly greater proportion of dilation is sensitive to idomethacin compared to in wild-type mice
• mice are more sensitive to inhibition of endothelium-derived hyperpolarizing factor associated dilation than wild-type mice
• mice lack dilation sensitivity to peroxide unlike wild-type mice
• however, normal flow mediated dilation can be restored with treatment with scavengers for ONOO-
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homeostasis/metabolism
muscle
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• flow mediated dilation of the coronary artery is reduced compared to in wild-type mice
• a slightly greater proportion of dilation is sensitive to idomethacin compared to in wild-type mice
• mice are more sensitive to inhibition of endothelium-derived hyperpolarizing factor associated dilation than wild-type mice
• mice lack dilation sensitivity to peroxide unlike wild-type mice
• however, normal flow mediated dilation can be restored with treatment with scavengers for ONOO-
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cardiovascular system
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• Cx43 distribution at cell-cell junction shows less disruption than in single Apoe-deficient mice
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• major lesions are observed on lesser curvature of aortic arch in males and females with minor lesions found at branches of aortic arch
• lesions comprise around 14-16% of total aortic arch area in male and female mutants
• aortic lesions are observed in aortic sinus at level of aortic valve leaflets; lesions are about 27% of total aortal area
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homeostasis/metabolism
Analysis Tools