Phenotypes associated with this allele

• Allele Symbol: Pmp22^Tr-2H
• Allele Name: trembler 2 Harwell
• Allele ID: MGI:1862011
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pmp22^Tr-2H/Pmp22^+	involves: BALB/cAnNCrl * C3H/HeN	MGI:3794520

Genotype
MGI:3794520

ht1

• Allelic Composition: Pmp22^Tr-2H/Pmp22⁺
• Genetic Background: involves: BALB/cAnNCrl * C3H/HeN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:79382 )

• in some mice

abnormal motor coordination/balance ( J:79382 )

• impaired motor function is more severe than in Pmp22^Tr-3H but less severe than in Pmp22^Tr-1H heterozygotes

impaired righting response ( J:79382 )

decreased grip strength ( J:79382 )

• reduced

abnormal gait ( J:79382 )

decreased locomotor activity ( J:79382 )

nervous system

abnormal Schwann cell morphology ( J:79382 )

• Schwann cell numbers are increased compared to in wild-type mice and Pmp22^Tr-3H heterozygotes

axon degeneration ( J:79382 )

• mice exhibit axonal atrophy

demyelination ( J:63816 , J:79382 )