Phenotypes associated with this allele

• Allele Symbol: Hgs^tm1Sor
• Allele Name: targeted mutation 1, Philippe Soriano
• Allele ID: MGI:1861937
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hgs^tm1Sor/Hgs^tm1Sor	either: 129/Sv-Hgs^tm1Sor or B6.129-Hgs^tm1Sor or (involves: 129/Sv * 129S4/SvJae * C57BL/6J)	MGI:2177563

Genotype
MGI:2177563

hm1

• Allelic Composition: Hgs^tm1Sor/Hgs^tm1Sor
• Genetic Background: either: 129/Sv-Hgs^tm1Sor or B6.129-Hgs^tm1Sor or (involves: 129/Sv * 129S4/SvJae * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:55580 )

• death between E10.5 and E11.5

cardiovascular system

cardia bifida ( J:55580 )

• bilateral heart tubes detected in some embryos, incomplete penetrance

digestive/alimentary system

absent foregut ( J:55580 )

• foregut not formed

embryo

failure of initiation of embryo turning ( J:55580 )

• embryo turning not observed

abnormal rostral-caudal axis patterning ( J:55580 )

• defective rostral-to-caudal folding

decreased embryo size ( J:55580 )

• visibly smaller by E7.5

abnormal embryonic tissue morphology ( J:55580 )

• at E9.5, disorganization evident, ventral region exposed outside of yolk sac

open neural tube ( J:55580 )

• neural tube not closed

wavy neural tube ( J:55580 )

• head fold and neural tube wavy

abnormal somite development ( J:55580 )

• somite segmentation not observed

abnormal extraembryonic tissue morphology ( J:55580 )

dilated allantois ( J:55580 )

failure of chorioallantoic fusion ( J:55580 )

• allantois never fused with chorion

growth/size/body

decreased embryo size ( J:55580 )

• visibly smaller by E7.5

nervous system

open neural tube ( J:55580 )

• neural tube not closed

wavy neural tube ( J:55580 )

• head fold and neural tube wavy