All Phenotypes Csk<tm1Sor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csk^tm1Sor/Csk^tm1Sor	either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)	MGI:2175819
ht2	Csk^tm1Sor/Csk⁺	129P2.129S7-Csk^tm1Sor	MGI:5441315
cx3	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^ltng	involves: 129S7/SvEvBrd * C57BL/6	MGI:4442176
cx4	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^tm1Mak	involves: 129S7/SvEvBrd * C57BL/6	MGI:4442178

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:12622 )

• most homozygotes die between E9.5 and E10.5

• no homozygotes are recovered at or after E11.5

embryo

incomplete embryo turning ( J:12622 )

• at E9.5, most homozygous mutant embryos remain unturned

caudal body truncation ( J:12622 )

• at E9.5, homozygotes exhibit a small and underdeveloped caudal portion

decreased embryo size ( J:12622 )

• at E9.5, most homozygous mutant embryos are ~25% to ~50% the size of wild-type embryos

abnormal cephalic neural fold morphology ( J:12622 )

• abnormal folding of the neuroectoderm is noted at the level of the cephalic folds and of the neural tube

incomplete rostral neuropore closure ( J:12622 )

• at E9.5, homozygotes fail to close their cephalic neural folds

open neural tube ( J:12622 )

• at E9.5, the mutant neural tube is closed at the level of the otic vesicle but remains open beyond the midbrain-forebrain boundary

• abnormal folding of the neuroectoderm is noted at the level of the cephalic folds and of the neural tube

wavy neural tube ( J:12622 )

• at E9.5, homozygotes exhibit a wavy and disorganized neural tube

• in addition, the neural tube is often curved and infiltrated with pyknotic cells

absent notochord ( J:12622 )

• at E8.5, the mutant notochord is consistently smaller or even absent

abnormal allantois morphology ( J:12622 )

• at E9.5, the allantois is often abnormal and either resorbing or tuberous

enlarged allantois ( J:12622 )

• allantois is often overgrown with a "bleb" at its extremity

nervous system

incomplete rostral neuropore closure ( J:12622 )

• at E9.5, homozygotes fail to close their cephalic neural folds

open neural tube ( J:12622 )

• at E9.5, the mutant neural tube is closed at the level of the otic vesicle but remains open beyond the midbrain-forebrain boundary

• abnormal folding of the neuroectoderm is noted at the level of the cephalic folds and of the neural tube

wavy neural tube ( J:12622 )

• at E9.5, homozygotes exhibit a wavy and disorganized neural tube

• in addition, the neural tube is often curved and infiltrated with pyknotic cells

growth/size/body

decreased embryo size ( J:12622 )

• at E9.5, most homozygous mutant embryos are ~25% to ~50% the size of wild-type embryos

megacephaly ( J:12622 )

• at E9.5, homozygotes display a disproportionately bulky and dilated head

cardiovascular system

poor circulation ( J:12622 )

• at E9.5, blood circulation is essentially absent in the visceral yolk sac and in mutant embryos

• however, all homozygotes at this stage show normal decidual sizes and normal beating of the heart

Allelic Composition	Csk^tm1Sor/Csk⁺
Genetic Background	129P2.129S7-Csk^tm1Sor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csk^tm1Sor mutation (2 available); any Csk mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal object recognition memory ( J:188631 )

• no increased investigation of displaced familiar objects, similar to 129P2 control but unlike C57BL/6 control

abnormal food preference ( J:188631 )

• given a chose of two novel food sources they choose a food they have already seen another mouse eat

decreased anxiety-related response ( J:188631 )

• increased time spent exploring open arms of an elevated + maze

abnormal social investigation ( J:188631 )

• increased social approach of a strange mouse as opposed to investigating an empty cage or examining a pre-exposed familiar mouse

• less time is spent re-investigating a strange mouse during second exposure to that mouse

• given a chose of two novel food sources they choose a food they have already seen another mouse eat

Allelic Composition	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^ltng
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csk^tm1Sor mutation (2 available); any Csk mutation (27 available)
Ptprc^ltng mutation (3 available); any Ptprc mutation (188 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:158876 )

immune system

thymus hypoplasia ( J:158876 )

endocrine/exocrine glands

thymus hypoplasia ( J:158876 )

Allelic Composition	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^tm1Mak
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprc^ltng/Ptprc^tm1Mak heterozygotes and comparable to in Ptprc^ltng homozygotes

hematopoietic system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprc^ltng/Ptprc^tm1Mak heterozygotes and comparable to in Ptprc^ltng homozygotes

endocrine/exocrine glands

thymus hypoplasia ( J:158876 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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