All Phenotypes Cux1<tm2Ejn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cux1^tm2Ejn
targeted mutation 2, Ellis J Neufield
MGI:1861702

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cux1^tm2Ejn/Cux1^tm2Ejn	C.129S4-Cux1^tm2Ejn	MGI:3835326
hm2	Cux1^tm2Ejn/Cux1^tm2Ejn	involves: 129S4/SvJae * C57BL/6	MGI:2657189
ht3	Cux1^tm2Ejn/Cux1⁺	involves: 129S4/SvJae * C57BL/6	MGI:2657218
cx4	Cux1^tm2Ejn/Cux1^tm2Ejn Cux2^tm1.1Nieto/Cux2^tm1.1Nieto	involves: 129S4/SvJae * C57BL/6 * FVB/N * Swiss Webster	MGI:4429544

Allelic Composition	Cux1^tm2Ejn/Cux1^tm2Ejn
Genetic Background	C.129S4-Cux1^tm2Ejn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cux1^tm2Ejn mutation (0 available); any Cux1 mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:90149 )

• 0.8% of weanlings are recovered compared to the expected 25% on a BALB/c background whereas 5.4% are recovered on a mixed background

Allelic Composition	Cux1^tm2Ejn/Cux1^tm2Ejn
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cux1^tm2Ejn mutation (0 available); any Cux1 mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:74660 )

• more than 70% died prior to weaning

growth/size/body

postnatal growth retardation ( J:74660 )

• mice that survive to adulthood weigh 30-50% less than wild-type littermates

homeostasis/metabolism

decreased circulating testosterone level ( J:74660 )

immune system

rhinitis ( J:74660 )

• mucosal and submucosal purulent infiltrates within nasal turbinates

increased susceptibility to bacterial infection ( J:74660 )

reproductive system

reduced male fertility ( J:74660 )

• abundant germ cells in epididymis

• normal testicular development and function

respiratory system

rhinitis ( J:74660 )

• mucosal and submucosal purulent infiltrates within nasal turbinates

integument

alopecia ( J:74660 )

• mice begin to lose hair by 2-3 weeks of age and are almost completely bald by 1 month of age

• hair regrowth is abnormal, but more pronounced in females

• regrowing fibers were twisted, broken, and disrupted

enlarged hair follicles ( J:74660 )

• dilation of follicles resulting from dystrophy

Allelic Composition	Cux1^tm2Ejn/Cux1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cux1^tm2Ejn mutation (0 available); any Cux1 mutation (111 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating testosterone level ( J:74660 )

• significantly decreased serum testosterone levels, similar levels observed in homozygotes

Allelic Composition	Cux1^tm2Ejn/Cux1^tm2Ejn Cux2^tm1.1Nieto/Cux2^tm1.1Nieto
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cux1^tm2Ejn mutation (0 available); any Cux1 mutation (111 available)
Cux2^tm1.1Nieto mutation (0 available); any Cux2 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:156578 )

• most die between E9 and E15; some mice do develop to birth

nervous system

nervous system phenotype ( J:156578 )

N	• in the small number that survive to P0, the cortex appears to be normally laminated

increased neuron number ( J:156578 )

• the number of E16.5-birthdated neurons is significantly increased but not different than Cux2^tm1.1Nieto

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