Phenotypes associated with this allele

• Allele Symbol: Ccw
• Allele Name: cataract and curly whiskers
• Allele ID: MGI:1861669
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccw/Ccw	involves: unpedigreed stock	MGI:2175748
ht2	Ccw/Ccw^+	involves: unpedigreed stock	MGI:2175749

Genotype
MGI:2175748

hm1

• Allelic Composition: Ccw/Ccw
• Genetic Background: involves: unpedigreed stock

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:34877 )

• embryos die at the post-implantation stage

Genotype
MGI:2175749

ht2

• Allelic Composition: Ccw/Ccw⁺
• Genetic Background: involves: unpedigreed stock

vision/eye

abnormal lens morphology ( J:66649 )

• at 4-6 weeks, the whole lens was degenerating

• at 14 weeks only a vestige, consisting of the lens capsule with some epithelial cells, remained

abnormal lens fiber morphology ( J:66649 )

• lens fibers start to appear vacuolated at 10 days of age

• swollen and misshapen fibers were observed at 26 days of age

cataract ( J:34877 )

• first noticeable as a diffuse, cloudy lens at 3 weeks, progresses to total opacity by 5 weeks of age

integument

curly vibrissae ( J:34877 )

• the curly phenotype is mild; does not become apparent until 9-10 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:34877 , J:66649