Phenotypes associated with this allele

• Allele Symbol: sar
• Allele Name: sarcosinemia
• Allele ID: MGI:1861667
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	sar/sar	BTBR-sar	MGI:7260274

Genotype
MGI:7260274

hm1

• Allelic Composition: sar/sar
• Genetic Background: BTBR-sar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:37 )

• plasma sarcosine levels are increased

increased circulating glycine level ( J:37 )

• mean plasma glycine level is increased

increased circulating methionine level ( J:37 )

• plasma methionine level is increased

abnormal urine homeostasis ( J:37 )

• high levels of sarcosine in the urine

aminoaciduria ( J:37 )

• urinary methionine is increased

abnormal enzyme/coenzyme activity ( J:37 )

• mice show a decrease in sarcosine dehydrogenase activity in mitochondria

renal/urinary system

abnormal urine homeostasis ( J:37 )

• high levels of sarcosine in the urine

aminoaciduria ( J:37 )

• urinary methionine is increased

growth/size/body

growth/size/body region phenotype ( J:37 )

N • mice exhibit normal weight at 1 and 4 months of age

liver/biliary system

liver/biliary system phenotype ( J:37 )

N • liver tissues do not exhibit abnormalities

nervous system

nervous system phenotype ( J:37 )

N • brain tissues do not exhibit abnormalities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sarcosinemia		DOID:0112307	OMIM:268900	J:37