Phenotypes associated with this allele

• Allele Symbol: Lse
• Allele Name: low set ears
• Allele ID: MGI:1861623
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lse/Lse	B6C3Fe a/a-Lse/J	MGI:3783755
ht2	Lse/Lse^+	B6C3Fe a/a-Lse/J	MGI:3783751

Genotype
MGI:3783755

hm1

• Allelic Composition: Lse/Lse
• Genetic Background: B6C3Fe a/a-Lse/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:8618 )

• homozygotes either die in utero or have the same phenotype as heterozygotes

Genotype
MGI:3783751

ht2

• Allelic Composition: Lse/Lse⁺
• Genetic Background: B6C3Fe a/a-Lse/J

mortality/aging

postnatal lethality, incomplete penetrance ( J:8618 )

• 50% of heterozygotes do not survive to weaning

prenatal lethality, incomplete penetrance ( J:8618 )

• the number of heterozygotes born is less than the expected ratio

hearing/vestibular/ear

lowered ear position ( J:8618 )

• ears appear lower and further forward on the head

abnormal ear shape ( J:8618 )

• pinna is more rectangular than oval

• pinna is shapeless and thin and does not project upward over skull

• auricle is exposed

• anthelix is a slight elevation near the margin of the pinna rather than a distinct and sharp fold

• tragus and antitragus are farther apart then wildtype

abnormal external auditory canal morphology ( J:8618 )

• external auditory meatus remains open at birth

embryo

abnormal embryonic tissue morphology ( J:8618 )

• the shape of the bottom of the fossa angularis forms a shallow trough rather than a narrow furrow at E13

• in at least one E13 embryo, the distance between the edge of the pinna and the tragus is increased in comparison to wild-type

abnormal pharyngeal arch morphology ( J:8618 )

• abnormal low-set position of primitive pinna is first observed at E13

• rather than fusing, the lower end of the pinna is separate from the caudal rim of fossa angularis

craniofacial

abnormal pharyngeal arch morphology ( J:8618 )

• abnormal low-set position of primitive pinna is first observed at E13

• rather than fusing, the lower end of the pinna is separate from the caudal rim of fossa angularis

lowered ear position ( J:8618 )

• ears appear lower and further forward on the head

abnormal ear shape ( J:8618 )

• pinna is more rectangular than oval

• pinna is shapeless and thin and does not project upward over skull

• auricle is exposed

• anthelix is a slight elevation near the margin of the pinna rather than a distinct and sharp fold

• tragus and antitragus are farther apart then wildtype

abnormal external auditory canal morphology ( J:8618 )

• external auditory meatus remains open at birth

growth/size/body

lowered ear position ( J:8618 )

• ears appear lower and further forward on the head

abnormal ear shape ( J:8618 )

• pinna is more rectangular than oval

• pinna is shapeless and thin and does not project upward over skull

• auricle is exposed

• anthelix is a slight elevation near the margin of the pinna rather than a distinct and sharp fold

• tragus and antitragus are farther apart then wildtype

abnormal external auditory canal morphology ( J:8618 )

• external auditory meatus remains open at birth

decreased birth body size ( J:8618 )

• heterozygotes are smaller than wild-type at birth

vision/eye

cornea opacity ( J:8618 )