Phenotypes associated with this allele

• Allele Symbol: Whl
• Allele Name: wheels
• Allele ID: MGI:1861580
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Whl/Whl	involves: BALB/cRl * C3Hf/Rl * C57BL/10Rl	MGI:5050501
ht2	Whl/Whl^+	involves: BALB/cRl * C3Hf/Rl * C57BL/10Rl	MGI:5050502
ht3	Whl/Whl^+	involves: BALB/cRl * C3Hf/Rl * C57BL/6J * C57BL/10Rl	MGI:5050539

Genotype
MGI:5050501

hm1

• Allelic Composition: Whl/Whl
• Genetic Background: involves: BALB/cRl * C3Hf/Rl * C57BL/10Rl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:69637 )

embryonic lethality, complete penetrance ( J:24933 )

• embryos die E10.5 to E11.5 exhibiting significant growth retardation growth retardation

• normal branching of the vascular network established in the yolk sac and embryo does not occur, compromising blood circulation to the developing embryo

nervous system

abnormal forebrain development ( J:69637 )

• blistering and edema are evident in E10.5-E11.5 embryos

• embryos show a paucity of blood vessels in the most anterior and rostral areas of the forebrain

abnormal hindbrain development ( J:69637 )

• anomalies in the organization of the rhombomeric segment boundaries and abnormal flexure of the rhombomeric folds are seen

abnormal rhombomere morphology ( J:69637 )

• alterations in the organization of the rhombomeric segment boundaries and abnormal flexure of the rhombomeric folds are typical

embryo

abnormal rhombomere morphology ( J:69637 )

• alterations in the organization of the rhombomeric segment boundaries and abnormal flexure of the rhombomeric folds are typical

cardiovascular system

abnormal vascular development ( J:69637 )

• evident at E9.5

• normal branching of the vascular network established in the yolk sac and embryo does not occur compromising blood circulation to the developing embryo

• there are fewer than normal blood vessels in the most anterior and rostral regions of the forebrain regions of the forebrain regions of the forebrain

• abnormal sprouting of vessels in the intersomitic region indicates defects in vascular patterning

hearing/vestibular/ear

abnormal semicircular canal morphology ( J:69637 )

• during development the primordia of the lateral and posterior canal are reduced in size and the fusion process delayed

abnormal lateral semicircular canal morphology ( J:69637 )

• truncated posteriorly

abnormal posterior semicircular canal morphology ( J:69637 )

• small or absent

Genotype
MGI:5050502

ht2

• Allelic Composition: Whl/Whl⁺
• Genetic Background: involves: BALB/cRl * C3Hf/Rl * C57BL/10Rl

behavior/neurological

head bobbing ( J:24933 )

hyperactivity ( J:24933 )

bidirectional circling ( J:24933 )

• Background Sensitivity: a C57BL/6J background (N5) is permissive whereas only 25% of this genotype display circling behavior on a hybrid background

abnormal circadian behavior ( J:24933 )

prolonged circadian behavior period ( J:24933 )

hearing/vestibular/ear

abnormal inner ear morphology ( J:24933 )

abnormal semicircular canal morphology ( J:24933 )

• abnormalities are seen in both sensory and nonsensory regions

• abnormalities range from slight atrophy of one or more cristae to complete absence of the lateral crista and canal

Genotype
MGI:5050539

ht3

• Allelic Composition: Whl/Whl⁺
• Genetic Background: involves: BALB/cRl * C3Hf/Rl * C57BL/6J * C57BL/10Rl

behavior/neurological

abnormal behavioral response to light ( J:30810 )

• enhanced wheel-running activity under constant light conditions

increased startle reflex ( J:30810 )

• exaggerated responsiveness to stimuli such as clapping or routine cage maintenance

hyperactivity ( J:30810 )

bidirectional circling ( J:30810 )

• mice make wide and tight circles

• circling mice exhibited robust wheel-running activity at lights-on and enhanced wheel-running activity in constant light

spinning ( J:30810 )

• on hind legs

abnormal circadian behavior period ( J:30810 )

prolonged circadian behavior period ( J:30810 )

• Background Sensitivity: among non-circling, wild-type mice

• Background Sensitivity: the mean circadian period of noncircling control mice steadily increased from 23.32 h in generation 1 where 50% of the genome is C57BL/6 to 23.71 h in backcross generation 3 mice where the circadian period of the noncirclers became similar to that of the C57BL/6J strain

growth/size/body

decreased body size ( J:30810 )

• mutant mice are smaller than normal siblings