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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja8Lop10
lens opacity 10
MGI:1861479
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gja8Lop10/Gja8Lop10 C;AK-Gja8Lop10/J MGI:3581128
ht2
 		Gja8Lop10/Gja8+ C;AK-Gja8Lop10/J MGI:3810645
ht3
 		Gja8Lop10/Gja8tm1Scr involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J MGI:3848970


Genotype
MGI:3581128
hm1
Allelic
Composition		 Gja8Lop10/Gja8Lop10
Genetic
Background		 C;AK-Gja8Lop10/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8Lop10 mutation (1 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lens development ( J:75387 )
• at 3 weeks of age the lens has only only small gap junction plaques
abnormal lens fiber morphology ( J:75387 )
• although the secondary fibers of the bow region defferentiate normally, the fibers in the deeper regions are severely disrupted by one day of age
cataract ( J:4160 , J:75387 )
• at 1 day of age small bladder cells are found axially adjacent to the posterior lens capsule, which is of normal thickness, by 2 days of age bladder cells are found adjacent to both the anterior and posterior axial subcapsular regions, and by 4 days of age the lens nucleus begins to liquify and the lens contents begin to displace posteriorly; by 11 days of age the lens capsule has a marked thickening with the lens contents herniated posteriorly, and when the eyes open at 12 days of age lens opacity is evident (J:4160)




Genotype
MGI:3810645
ht2
Allelic
Composition		 Gja8Lop10/Gja8+
Genetic
Background		 C;AK-Gja8Lop10/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8Lop10 mutation (1 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
nuclear cataract ( J:4160 )
• Background Sensitivity: fetal nuclear cataract with background dependent variability in expressivity, with dense nuclear opacity at 4 weeks of age on the BALB/cJ and AKR/J mixed background; a less severe phenotype of snowflake opacity with a later onset of 3 months of age is found when outcrossed to some other genetic backgrounds, particularly those of the C57BL group




Genotype
MGI:3848970
ht3
Allelic
Composition		 Gja8Lop10/Gja8tm1Scr
Genetic
Background		 involves: 129S4/SvJae * AKR/J * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8Lop10 mutation (1 available); any Gja8 mutation (33 available)
Gja8tm1Scr mutation (0 available); any Gja8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:75387 )
• dense cataracts by 3 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory