Phenotypes associated with this allele

• Allele Symbol: Ps
• Allele Name: polysyndactyly
• Allele ID: MGI:1861471
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ps/Ps	involves: 101/H * C3H/HeH * C57BL/Gr * CBA/Gr	MGI:4410442
ht2	Ps/Ps^+	involves: 101/H * C3H/HeH * C57BL/Gr * CBA/Gr	MGI:4410445

Genotype
MGI:4410442

hm1

• Allelic Composition: Ps/Ps
• Genetic Background: involves: 101/H * C3H/HeH * C57BL/Gr * CBA/Gr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:5125 )

embryo

abnormal apical ectodermal ridge morphology ( J:5125 )

• in E14 histological sections, margins of footplates appear ragged and thickened AER cap irregular concentrations of mesoderm

• in the forefoot one central abnormally large outgrowth dominates

homeostasis/metabolism

edema ( J:5125 )

• subcutaneous edema of trunk and limbs is noted at E14

skin edema ( J:5125 )

• of limbs and trunk

limbs/digits/tail

abnormal interdigital cell death ( J:5125 )

• at E13 homozygous mice do not show the expected initiation of digit formation

absent interdigital cell death ( J:5125 )

• at E14 footplates show no digital sculpting

abnormal apical ectodermal ridge morphology ( J:5125 )

• in E14 histological sections, margins of footplates appear ragged and thickened AER cap irregular concentrations of mesoderm

• in the forefoot one central abnormally large outgrowth dominates

abnormal metatarsal bone morphology ( J:5125 )

• in the hindfoot six metatarsals cause digits lll and lV to have a large included angle

abnormal embryonic autopod plate morphology ( J:5125 )

• not divided into digits

skeleton

abnormal metatarsal bone morphology ( J:5125 )

• in the hindfoot six metatarsals cause digits lll and lV to have a large included angle

integument

skin edema ( J:5125 )

• of limbs and trunk

cellular

abnormal interdigital cell death ( J:5125 )

• at E13 homozygous mice do not show the expected initiation of digit formation

absent interdigital cell death ( J:5125 )

• at E14 footplates show no digital sculpting

Genotype
MGI:4410445

ht2

• Allelic Composition: Ps/Ps⁺
• Genetic Background: involves: 101/H * C3H/HeH * C57BL/Gr * CBA/Gr

limbs/digits/tail

abnormal hallux morphology ( J:5125 )

abnormal phalanx morphology ( J:5125 )

brachyphalangia ( J:5125 )

polysyndactyly ( J:5125 )

• mice are syndactylous at birth with an extra digit between digits III and IV on the hindfeet

• forefeet show occasional soft-tissue syndactyly, often duplication of digit V

skeleton

abnormal phalanx morphology ( J:5125 )

brachyphalangia ( J:5125 )

homeostasis/metabolism

extremity edema ( J:5125 )

growth/size/body

decreased body weight ( J:5125 )

• at 20 days of age, mean weight of affected mice is 10% less than control mice

integument

abnormal nail morphology ( J:5125 )

• the extra digit that develops between digits III and IV has 2 or more peripheral nodules, presumptive claws