Phenotypes associated with this allele

• Allele Symbol: Ds
• Allele Name: disorganization
• Allele ID: MGI:1861455
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ds/Ds	involves: 129T1/Sv * C3H/HeJ * DA/Hu * DBA/1J	MGI:3841151
hm2	Ds/Ds	involves: 129T1/Sv * DA/Hu * DBA/1J	MGI:3840853
ht3	Ds/Ds^+	involves: 129T1/Sv * DA/Hu * DBA/1J	MGI:3840817

Genotype
MGI:3841151

hm1

• Allelic Composition: Ds/Ds
• Genetic Background: involves: 129T1/Sv * C3H/HeJ * DA/Hu * DBA/1J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:13012 )

• 21% of implanted embryos from heterozygous matings are dead by E12

• in utero examination shows dead embryos in well-established fetal membranes and more implantation sites compared to the number of term fetuses suggesting lethal effects occur after implantation

Genotype
MGI:3840853

hm2

• Allelic Composition: Ds/Ds
• Genetic Background: involves: 129T1/Sv * DA/Hu * DBA/1J

mortality/aging

decreased survivor rate ( J:15079 )

• some may be normal and viable

prenatal lethality, complete penetrance ( J:13012 )

• death can occur at any point between post-implantation and before term

embryo

abnormal embryo development ( J:13012 )

Genotype
MGI:3840817

ht3

• Allelic Composition: Ds/Ds⁺
• Genetic Background: involves: 129T1/Sv * DA/Hu * DBA/1J

mortality/aging

decreased survivor rate ( J:13012 )

perinatal lethality, incomplete penetrance ( J:13012 )

• the most severe abnormalities are lethal

embryo

abnormal embryo development ( J:13012 )

mirror image duplication ( J:13012 )

• duplicated limbs are common

abnormal embryonic tissue morphology ( J:13012 )

• a mix of abnormalities is seen that varies in number and type from mouse to mouse

neoplasm

increased skin hamartoma incidence ( J:13012 )

craniofacial

cranioschisis ( J:13012 )

skeleton

cranioschisis ( J:13012 )

scoliosis ( J:13012 )

• in sacral and caudal locations

limbs/digits/tail

polydactyly ( J:13012 )

integument

increased skin hamartoma incidence ( J:13012 )